نتایج جستجو برای: q22
تعداد نتایج: 928 فیلتر نتایج به سال:
BACKGROUND The current WHO classification of hematologic malignancies defines distinct entities of myeloid disorders based on the presence of recurrent cytogenetic abnormalities. Diagnostic clonal chromosomal abnormalities provide important prognostic information and are among the most important factors in predicting initial response to chemotherapy, duration of remission and overall survival. ...
OBJECTIVES The present study aimed to examine the cytogenetic and genetic mutation features of acute myeloid leukemia (AML) in elderly Chinese patients. METHODS A retrospective analysis of cytogenetics and genetic mutations was performed in 113 cases (age range 50-82 years) with de novo AML. RESULTS The most frequent cytogenetic abnormality was t (15;17) (q22;q21), detected in 10.0% (n = 9)...
Pretreatment clinical features and prognosis of patients with acute myeloid leukemia (AML) are strongly influenced by acquired genetic alterations in leukemic cells, which include microscopically detectable chromosome aberrations and, increasingly, submicroscopic gene mutations and changes in gene expression. Cytogenetic findings separate AML patients into three broad prognostic categories: fav...
Malignant fibrous histiocytoma (MFH) of bone is a rare, highly malignant tumour. As very little is known about its genetic alterations, 26 bone MFHs were analysed by comparative genomic hybridisation (CGH). Twenty-three tumours (89%) had DNA sequence copy number changes (mean, 7.2 changes per sample). Gains were more frequent than losses (gains:losses=2.5:1). Minimal common regions for the most...
(for review, see Orkin, 1995). A transcription factor complex that plays a central role in hematopoiesis is the 1 unit can bind DNA as a monomer in vitro, but its affinity 1 Department of Biochemistry for DNA is 5-to 10-fold greater when it binds DNA as Dartmouth Medical School a CBF␣: heterodimer (Ogawa et al., 1993a; Wang et al., Hanover, New Hampshire 03755 1993). The only function ascribed...
The majority of chromosome rearrangements are balanced reciprocal and Robertsonian translocations. It is now known that such abnormalities cause no phenotypic effect on the carrier but lead to increased risk of producing unbalanced gametes. Here, we report the inheritance of a translocation between chromosomes 3 and 21 in a family with one of two fetuses with Down Syndrome carrying the same tra...
The purpose of the clinical case was to describe combination chromosome abnormaliries in girl with malformations large intestine.Girl A., 1, 9 year old born prematurely. From birth, multiple stigmas dysembriogenesis: poor weight gain, absence an independent stool, marked delayed physical and psychomotor development attracted attention. During doppler echocardiography, a left-sided right- formed...
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