Este estudo teve por objetivo identificar e descrever as principais alterações citogenéticas biomoleculares encontradas na Leucemia Mieloide Aguda (LMA). Métodos– Foi feita uma revisão de literatura com pesquisa artigos nos bancos dados Scientific Electronic Library Online (SciELO), National Center for Biotecnology Information (NCBI), Literatura Latino-Americana do Caribe em Ciências da Saúde (...

The report by Ball et all showed the significance of the lymphoid markers, CD2 and CD19 antigens, expressed by subsets of acute myeloblastic leukemia (AML) in correlation with chromosomal aberrations and prognosis. The report disregarded CD7 antigen as lymphoid marker, probably because the relatively high incidence of the expression of CD7 antigen in AML cases, compared with CD2 or CD19 antigen...

The t(8;21)(q22;q22) translocation is specifically observed in acute myeloid leukemia (AML) M2 subtype, whereas del(5q) is one of the most common cytogenetic aberrations in myelodysplastic syndromes (MDS). Thus, t(8;21)(q22;q22) and del(5q) appear to be mutually exclusive, and the association between them has not been characterized yet. Here, we report an 81-year-old woman with coexistent t(8;2...

The t(8;21)(q22;q22) is one of the most frequent chromosomal abnormality associated with acute myeloid leukemia (AML) M2 sub type. The additional chromosomal abnormalities including structural and numerical are frequently reported with the translocation, t (8;21)(q22;q22). We report a case of AML-M2 with t(X;8;21)(p22;q22;q22) associated with loss of Y chromosome. Using a dual color fluorescenc...

The aberrant expression of the B-cell transcription factor PAX5 has been described in a subset of acute myeloid leukemia (AML) with t(8;21)(q22;q22) in association with B-cell antigen expression. However, the expression of other B cell-associated transcription factors, particularly OCT-2 and its B cell-specific coactivator BOB.1, has not been described in AML. In this study, expression of PAX5,...

The t(8;21)(q22;q22) translocation involving RUNX1 at 21q22 and RUNX1T1 at 8q22 is found in 10% of cases of acute myeloid leukemia (AML) M2 subtype. This translocation results in the formation of a RUNX1/RUNX1T1 fusion gene, which contributes to leukemic transformation by transcriptional repression of normal RUNX1 target genes, on der (8)t(8;21)(q22;q22). AML with t(8;21) is usually associated ...