In inbred strains of mice, antiphosphorylcholine (PC) and anti-alpha 1,3 dextran (DEX) antibodies are structurally distinct from each other and have been shown to exhibit noncross-reactive antigen binding and idiotypic specificities. However, the prototype anti-PC and anti-DEX antibodies, TEPC15 and J558, respectively, were shown to be connected via a common autoantiidiotypic monoclonal antibod...

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BACKGROUND Many placebo-controlled trials have demonstrated the efficacy of individual pharmacotherapies approved for smoking cessation. However, few direct or indirect comparisons of such interventions have been conducted. We performed a meta-analysis to compare the treatment effects of 7 approved pharmacologic interventions for smoking cessation. METHODS We searched the US Centers for Disea...

Systematic review of published population based surveys to examine the relationship between primary open angle glaucoma (POAG) prevalence and demographic factors. A literature search identified population-based studies with quantitative estimates of POAG prevalence (to October 2014). Multilevel binomial logistic regression of log-odds of POAG was used to examine the effect of age and gender amo...

Previously, we isolated a Vk gene (Humkv325) from a human placenta that encodes RF light chains bearing the PSL2 and PSL3 CRI markers. Here we report the isolation and characterization of a second human Vk gene (Humkv328) that can be used for RF synthesis. This Vk gene probably encodes at least two 6B6.6 CRI+ RF light chains (Les and Pom) from unrelated subjects, and thus may be related to the ...

OBJECTIVES To reflect on the notable events and significant developments in Clinical Research Informatics (CRI) in the year of 2015 and discuss near-term trends impacting CRI. METHODS We selected key publications that highlight not only important recent advances in CRI but also notable events likely to have significant impact on CRI activities over the next few years or longer, and consulted ...

BALB/c mice immunized with bacterial levan (BL), a /3(2---*6) fructosan with fl(2--*l) branched points, produce antibodies of two general types (1). One group of molecules is specific for inulin, which is a fl(2---* 1) fructosan, as well as for levan; such antibodies, which can first be detected in BALB/c mice at 28 d of age (2), express idiotypes (Id) that cross-react with those found on inuli...

The present study was conducted to investigate the response of two wheat cultivars (AARI-11 and Millat-11) to a foliar application of four growth enhancers which include: {H2O (water), MLE30 (moringa leaf extract), KCl (potassium chloride), and BAP (benzyl-amino purine)}, within the six irrigation water-regimes which are applied at the various critical growth stages such as crown root initiatio...

BACKGROUND Smoking is still gaining ground in Sub-Saharan Africa, especially among socially disadvantaged groups. People living with HIV represent a subgroup with a significantly elevated prevalence of cigarette smoking. The objective of the study was to examine the influence of individual-, neighbourhood- and country-level socioeconomic position on current cigarette smoking among people living...