نتایج جستجو برای: receptor dependent cancers
تعداد نتایج: 1262609 فیلتر نتایج به سال:
Background & Objective: In Triple-Negative Breast Cancers (TNBCs), estrogen receptor (ER), progesterone receptor (PR) and HER2/neu genes are not expressed. Fibroblastic Growth Factor Receptor-1 (FGFR1) gene product is a protein that acts as a receptor of thyrosin kinase. It plays a role in the proliferation, differentiation, and migration of malignant cells. The objective was t...
Immunotherapy of malignant tumors is making progress towards improving patient survival with some cancers. The Herceptin antibody which targets a critical growth factor receptor on breast cancers has significantly improved survival in those women whose tumors over-express that receptor. Not only does Herceptin receptor blockade interfere with a key growth factor signaling pathway on the tumor c...
Opioid growth factor (OGF) is an endogenous opioid peptide ([Met(5)]-enkephalin) that interacts with the OGF receptor (OGFr). OGF serves as a constitutively expressed and tonically active negative growth factor in neoplasia, and the OGF-OGFr axis contributes to the maintenance of an equilibrium in cell replication by targeting cyclin-dependent inhibitory kinase pathways. In a previous study, OG...
High-grade serous ovarian cancers (HGSOC) are genomically complex, heterogeneous cancers with a high mortality rate, due to acquired chemoresistance and lack of targeted therapy options. Cyclin-dependent kinase inhibitors (CDKi) target the retinoblastoma (RB) signaling network, and have been successfully incorporated into treatment regimens for breast and other cancers. Here, we have compared m...
this research study aimed to investigate the relationship between field-dependence/independence cognitive style and vocabulary learning strategies among iranian efl learners. ninety participants majoring in english translation at arak university were chosen. the participants were classified into two groups of field-dependent and independent based on the results of group embedded figure test (ge...
Kallikrein 4 (KLK4) is a member of the human KLK gene family of serine proteases, many of which are implicated in hormone-dependent cancers. Like other KLKs, such as KLK3/PSA and KLK2, KLK4 gene expression is also regulated by steroid hormones in hormone-dependent cancers, although the transcriptional mechanisms are ill defined. Here, we have investigated the mechanisms mediating the hormonal r...
objective(s): angiotensin ⅱ type 1 receptor blockers (arbs) represent one of the widely used antihypertensive agents. in addition to anti-hypertension effect, some arbs also show other molecular effects such as activating peroxisome proliferator-activated receptor-γ and so on. here we studied the effects of telmisartan on the rat isolated mesenteric artery rings pre-contracted by phenylephrine ...
Dextromethorphan is an NMDA receptor antagonist in the glutamatergic system. Currently, there are some reports showing that the glutamatergic NMDA receptor mechanism stimulates dopamine release from several brain regions. This effect may in part modulate the stereotyped behaviors of dopaminergic system. The purpose of the present study was to determine the interaction between the blockade of NM...
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