In order to realise the full potential of cancer suicide gene therapy that allows the precise expression of suicide gene in cancer cells, we used a tissue specific Epithelial cell adhesion molecule (EpCAM) promoter (EGP-2) that directs transgene Herpes simplex virus-thymidine kinase (HSV-TK) expression preferentially in EpCAM over expressing cancer cells. EpCAM levels are considerably higher in...

Objective(s): This study focused on determining cytotoxic effects of copper oxide nanoparticles (CuO NPs) on chronic myeloid leukemia (CML) K562 cell line in a cell-specific manner and its possible mechanism of cell death. We investigated the cytotoxicity of CuO NPs against K562 cell line (cancerous cell) and peripheral blood mononuclear cell (normal cell). Materials and Methods: The toxicity w...

Background Autophagy is associated with the occurrence and progression of a variety diseases, such as cancers, cardiovascular autoimmune diseases. Ankylosing spondylitis (AS) chronic inflammatory disease. Its pathological feature includes local infiltration cells among which macrophages play dominant role [1]. Currently, previous studies have confirmed that autophagy may be involved in developm...

Type 2 diabetes mellitus (T2DM) is an intricate and inadequately treatable metabolic disorder that requires modified treatment by identifying genetic variants as potential drug targets. In this study, we performed the system-level analysis of T2DM-related cDNA dataset revealed 5 significant differentials expressed genes (DEGs) including ABRA, CYR61, NR4A1, KY, TMEM131 source genes. Among, these...

Abstract Background Breast cancer 2, early onset ( BRCA2 ) is a tumor suppressor gene. The protein encoded by this gene plays an important role in homologous recombination (HR)-mediated DNA repair. Deleterious mutations and downregulation of its expression have been associated with tumorigenesis dogs humans. Thus, regulation level for maintaining homeostasis recombination. Results In study, the...

To elucidate the molecular mechanism underlying high metastasis rate of brain for non-small cell lung cancer patients and to establish a comprehensive differential gene profile metastasis. The differentially expressed genes were systematically investigated. enriched biological processes signaling pathways explored. protein-protein interaction network was constructed. Compared with primary cance...