background: in this study, we aim to compare insulin and leptin levels in adolescents with or without overweight and in those with or without abdominal obesity. materials and methods: this case-control study was conducted among 486 samples. we randomly selected 243 overweight and an equal number of normal-weight adolescents from among participants of the third survey of a national surveillance ...

OBJECTIVE Estrogen plays an important role in feeding and energy balance, and the critical role of estrogen in the control of appetite and energy balance is mediated by hypothalamic estrogen receptor (ER) alpha. In undernourished rodents, hypothalamic ER alpha mRNA expression are decreased. Responses of some hypothalamic factors to negative energy balance develop during the early neonatal perio...

background ghrelin, a 28 amino acid peptide, is effective in control of appetite and body weight. acylated ghrelin peptide is the active form of this peptide which plays a major role in the body’s energy balance. objectives this study aimed to investigate the possible effect (s) of intensive resistance exercise on acylated ghrelin, growth hormone, glucose, insulin, and cortisol plasma levels. p...

resistance exercise is associated with increased oxidative stress. however, it is not completely obvious how resistance training intensity can affect the rest levels of oxidative stress indexes. therefore, the aim of the present research was to study the effect of moderate resistance (mr) and high resistance (hr) training on oxidative stress. 20 males (age: 20.6±0.7 yr, height: 1.74±0.06 m, wei...

Loss of body fat in leptin-treated animals has been attributed to reduced energy intake, increased thermogenesis, and preferential fatty acid oxidation. Leptin does not decrease food intake or body fat in leptin-resistant high-fat (HF)-fed mice, possibly due to a failure of leptin to activate hypothalamic receptors. We measured energy expenditure of male C57BL/6 mice adapted to low-fat (LF) or ...

Hypothalamic proopiomelanocortin (POMC) neurons constitute a critical anorexigenic node in the central nervous system (CNS) for maintaining energy balance. These neurons directly affect energy expenditure and feeding behavior by releasing bioactive neuropeptides but are also subject to signals directly related to nutritional state such as the adipokine leptin. To further investigate the interac...