In developing industries rms have to decide whether and when to enter the market depending on the state of demand, existing rms in the industry, and the rm's capabilities. This paper investigates a model of increasing demand, in which rms decide when to enter the market anticipating the strategic behavior of other potential entrants, and the e ects of entry on future potential entrants. The pap...

Rhabdomyosarcoma (RMS) is a childhood cancer originating from skeletal muscle, and patient survival is poor in the presence of metastatic disease. Few determinants that regulate metastasis development have been identified. The receptor tyrosine kinase FGFR4 is highly expressed in RMS tissue, suggesting a role in tumorigenesis, although its functional importance has not been defined. Here, we re...

Exploiting the lytic life cycle of viruses has gained recent attention as an anticancer strategy (oncolysis). To explore the utility of adenovirus (Ad)-mediated oncolysis for rhabdomyosarcoma (RMS), we tested RMS cell lines for Ad gene transduction and infection. RMS cells were variably transduced by Ad. Compared with control cells, RMS cells were less sensitive or even resistant to oncolysis b...

We observed that human rhabdomyosarcoma (RMS) cells highly express a tissue factor that promotes thrombin formation, which indirectly and directly affects RMS progression. First, we found that thrombin activates platelets to generate microvesicles (PMV), which transfer to RMS cells' alpha2beta3 integrin and increase their adhesiveness to endothelial cells. Accordingly, RMS cells covered with PM...

Rhabdomyosarcoma (RMS) is a malignant skeletal muscle neoplasm. RMS can occur anywhere in the body and is the most common childhood sarcoma (1). Pediatric RMS is an aggressive neoplasm with deregulated cell cycle checkpoints, high genome instability, and oncongene ampli ication such as MYC family members (2). However, RMS rarely occurs in adults. Moreover, sarcomas of the kidney are rare soft t...

We define Recursive Matrix Systems (RMS), a highly parameterizable formalism that allows for a clear separation of various kinds of recursion. One instance of RMS, namely context-free RMS with two rows and a specific reading interpretation turns out to be weakly equivalent to TAG. This allows for the transfer ofresults from TAGs to this dass of RMS. Furthermore, the equivalence proof is constru...

A Computer-Aided-Test (CAT) platform has been integrated in the Cadence Design Framework Environment for the evaluation of analogue/mixed-signal/RF Built-In-Self-Test (BIST) techniques. It comprises tools for statistical modelling of circuit performances, fault simulation, test generation and test optimization. The fault modelling and fault injection tools are simulator-independent, thus they a...