The role of central mu- and kappa-opioid receptors in the regulation of itch sensation was examined using pruritogen-induced mouse scratching behavior model. Intracerebroventricular administration of beta-funaltrexamine, a selective mu-opioid receptor antagonist, inhibited the scratching behavior induced by intradermal substance P, but subcutaneous administration of beta-funaltrexamine did not....

A novel method of digital scratching is presented as an alternative to currently available digital hardware interfaces and time-coded vinyl (TCV). Similar to TCV, the proposed method leverages existing analog turntables as a physical interface to manipulate the playback of digital audio. To do so, however, an accelerometer/gyroscope–equipped smart phone is firmly attached to a modified record, ...

Tinea corporis is a fungal infection of the body caused by Dermatophytes. characterised circinate eruptions, itching, burning, soreness and secondary infections. This case represents Corporis treated with homoeopathic remedy Mercurius Solubilis, A 47 year old male came in our OPD on 14/11/2023 complaints papulovesicular ring shaped eruption thigh which spread all over mostly trunk. Intense itch...

In this paper, we report a method for atomic force microscopy surface modifications with singletone and multiple-resolution Lissajous trajectories. The tip mechanical scratching experiments with two series of Lissajous trajectories were carried out on monolayer films. The scratching processes with two scan methods have been illustrated. As an application, the tip-based triboelectrification phen...

Nanoscratching-induced deformation in monocrystaline silicon is found to depend on the loading conditions. Molecular dynamics simulations reveal that amorphous phase transformation and nanotwins are the two major mechanisms. At a relatively low scratching depth, amorphous transformation occurs on the surface; however, when the scratching depth is greater than 1 nm, nanotwinning also emerges in ...

We present results of a hybrid experimental and theoretical investigation of the fracture scaling in scratch tests and show that scratching is a fracture dominated process. Validated for paraffin wax, cement paste, Jurassic limestone and steel, we derive a model that provides a quantitative means to relate quantities measured in scratch tests to fracture properties of materials at multiple scal...

Abstract In this study, a modeling approach based on smooth particle hydrodynamics (SPH) was implemented to simulate the nanoscale scratching process using conical tools with different negative rake angles. The model enables study of topography groove profiles, forces, and residual plastic strain beneath groove. An elastoplastic material employed for workpiece, tool–workpiece interaction define...