Concomitant administration of bevacizumab and pemetrexed-cisplatin is a common treatment for advanced nonsquamous non-small cell lung cancer (NSCLC). Vascular normalization following bevacizumab administration may transiently enhance drug delivery, suggesting improved efficacy with sequential administration. To investigate optimal scheduling, we conducted a study in NSCLC-bearing mice. First, e...

Production planning and control within modern manufacturing enterprises is a very complex process. The planning process encompasses decision making that spans from the macro level, such as market forecasting and master production scheduling, down to detail planning on the shop floor, such as the dispatching and sequencing of individual parts orders on a particular machining centre. This paper p...

preventive maintenance scheduling of generating units is addressed as a long-term scheduling in power system studies aiming to increase the reliability incorporating cost reduction. it consists of knowing which generating units should be shut down for regular safety inspection. in this paper, a new formulation of preventive maintenance scheduling associated with cost reduction index (cri) is pr...

In the field of predictive–reactive scheduling methods, group sequencing is reputed to be robust (in terms of uncertainties absorption) due to the flexibility it adds with regard to the sequence of operations. However, this assumption has been established on experiments made on simple theoretical examples. The aim of this paper is to carry out experimentation on a complex flexible manufacturing...

task graph scheduling is a multi-objective optimization and np-hard problem. in this paper a new algorithm on homogeneous multiprocessors systems is proposed. basically, scheduling algorithms are targeted to balance the two parameters of time and energy consumption. these two parameters are up to a certain limit in contrast with each other and improvement of one causes reduction in the other on...

Background and Objectives: Operating room (OR) scheduling is key to optimal operating room productivity. The significant uncertainty associated with surgery duration renders scheduling of surgical operation a challenging task. This paper proposes a novel computational stochastic model to optimize scheduling of surgeries with uncertain durations. The model considers various surgical operation co...

New competitive results for the stochastic resource-constrained project scheduling problem: exploring the benefits of pre-processing We study the resource-constrained project scheduling problem with stochastic activity durations. We introduce a new class of scheduling policies for solving this problem, which make a number of a-priori sequencing decisions in a pre-processing phase while the rema...

background : the sequencing batch reactor (sbr) is one of the most widely used systems in sewage treatment because of the simplicity of the process, flexibility of operation in the removal of nutrients, and the ability to be used in different scales. the aim of this study was to evaluate the efficiency of the sbr in the removal of organic matter (nitrogen and phosphorus) from synthetic wastewat...

this paper presented a mixed integer programming for integrated scheduling and process planning. the presented process plan included some orders with precedence relations similar to multiple traveling salesman problem (mtsp), which was categorized as an np-hard problem. these types of problems are also called advanced planning because of simultaneously determining the appropriate sequence and m...