Objective: To assess the association among serum insulinlike growth factor I (IGF-I) concentrations, bone mineral density (BMD), and biochemical markers of bone turnover in a large group of postmenopausal women from the general population. Design: As an extension of a larger epidemiological study, the Iranian Multicentral Osteoporosis Study, a total of 406 healthy postmenopausal women (age, 59....

Introduction: Liver plays a pivotal role in glucose and lipid homeostasis. This study was undertaken to evaluate the effects of L. acanthodes hydro-alcoholic extract administration on the liver functional and histological parameters in hyperglycemic rats. Methods: Twenty-four male Wistar rats were randomly allocated into four groups control, hyperglycemic (STZ), hyperglycemic + insulin (STZ...

OBJECTIVE/HYPOTHESIS Idiopathic benign paroxysmal positional vertigo (BPPV) is a strong indicator of decreased bone density (osteopenia/osteoporosis) in postmenopausal women, and there is a correlation between BPPV and serum levels of biochemical markers of bone turnover. STUDY DESIGN Prospective pilot clinical trial. METHODS Two groups of postmenopausal women were recruited. The BPPV group...

OBJECTIVE In this study, we aimed to evaluate whether the changes in the first and second trimester maternal serum biochemical markers used for prenatal screening are associated with euploid pregnancies complicated by intrahepatic cholestasis of pregnancy (ICP). METHODS A total of 94 pregnant women were included in this retrospective comparative study. Thirty-seven women whose pregnancy was c...

BACKGROUND Liver biopsy is thought mandatory for management of patients with hepatitis C virus (HCV) infection, especially for staging fibrosis. We aimed, in our prospective study, to assess the predictive value of a combination of basic serum biochemical markers for diagnosis of clinically significant fibrosis (including early stages). METHODS We assessed liver-biopsy patients with detectabl...

Abstract Objectives Roles of Thrombospondin-1 (TSP-1) and Thrombospondin-2 (TSP-2) in tissue repair inflammation are well-documented, but the association their serum expressions with pathogenesis COVID-19 remains unclear. We investigate roles TSP-1 TSP-2 COVID-19. Methods 106 SARS-CoV-2 infected patients 23 healthy people were enrolled our study. divided into two groups as non-severe severe. co...

Rheumatic disorders are viewed as a public health issue because they affect thousands of individuals around the world and increase care expenses. Numerous biochemical markers may play role in pathophysiology etiology rheumatoid arthritis (RA) due to its local well systemic inflammatory effects. Rheumatoid factors (RF) can be found variety people, including young, healthy elderly, people ...

The aims of this study were to determine some major biochemical alterations observed in first calving cows with udder edema during the periparturient period and to detect some associations between dietary factors and the disease. For that, the concentrations of some electrolytes (Na+, K+, Cl, Ca2+, P and Mg2+), lipid (triglycerides and cholesterol) markers and lipoproteins (HDL, LDL and VLDL) a...

Background: Parkinson’s disease (PD) is one of the most common neurodegenerative diseases (ND). Studies have demonstrated that biochemical markers have an association with PD. We aimed to investigate an association of biochemical markers including calcium, vitamin D, alkaline phosphatase (ALP), parathormone (PTH), and phosphorous with PD. Methods: This study was conducted on 139 PD patients an...

OBJECTIVE To estimate the difference between levels of the two biochemical markers pregnancy-associated plasma protein-A (PAPP-A) and maternal serum free β-human chorionic gonadotropin (free β-hCG) in twin pregnancies relative to singleton pregnancies and establish an improved screening procedure for chromosomal abnormalities such as trisomy 21 in twin pregnancies. METHODS 4843 unaffected and...