The survival of B6D2F1 female mice exposed to lethal doses of fission neutron radiation is increased when trehalose dimycolate (TDM) preparations are given either 1 h after exposure or 1 day before exposure to radiation. TDM in an emulsion of squalene, Tween 80, and saline was the most effective formulation for increasing the 30-day survival of mice when given 1 day before (90%) or 1 h after (8...

We conducted laboratory experiments to investigate the lethal and sublethal effects of clothianidin on bumble bee, Bombus impatiens Cresson, colony health and foraging ability. Bumble bee colonies were exposed to 6 ppb clothianidin, representing the highest residue levels found in field studies on pollen, and a higher dose of 36 ppb clothianidin in pollen. Clothianidin did not effect pollen con...

Interaction between radiation and Adriamycin damage reduced the width of the shoulder of the X-ray survival curve. This effect was found to persist for at least 24 hr after Adriamycin treatment. Adriamycin did not affect radiation damage when cells were treated either before two-dose fractionation or with the drug present between X-ray exposures. Adriamycin is unique in that its major effect on...

Differences in the pathogenesis of radiation-induced lung injury among murine strains offer a unique opportunity to elucidate the molecular mechanisms driving the divergence in tissue response from repair and recovery to organ failure. Here, we utilized two well-characterized murine models of radiation pneumonitis/fibrosis to compare and contrast differential gene expression in lungs 24 hours a...

The effects of a sublethal dose of Dieldrin (7.2 x 10(-5) g/day) were evaluated on oxygen consumption, survivorship, moulting and reproduction of Rhodnius prolixus. No difference was found in oxygen consumption between treated and control male insect. Survivorship proved to be very much affected by the sublethal exposure, but this was strongly dependent on the feeding stage of the individuals. ...

Exposure to antibiotics induces the expression of mutagenic bacterial stress-response pathways, but the evolutionary benefits of these responses remain unclear. One possibility is that stress-response pathways provide a short-term advantage by protecting bacteria against the toxic effects of antibiotics. Second, it is possible that stress-induced mutagenesis provides a long-term advantage by ac...

Copper sulphate, CuSO4.5H2O (Fine Chemical, India), Purity (99%) and CAS No. 7758-98-7, a broad-spectrum inorganic pesticide, has many-fold uses as fungicide, molluscicide and weedicide. The adult Indian skittering frog, Euphlyctis cyanophlyctis was treated In vivo with different sublethal concentrations of CuSO4 (3.5, 5.0, 6.5 and 8.0mg/kg) after calculating the LC50 value which was found to b...

Toxicity induced by nitric oxide (NO(*)) has been extensively investigated in many in vitro and in vivo experimental models. Recently, our laboratories found that both concentration and cumulative total dose are critical determinants of cell death caused by NO(*). Here, we report results of studies designed to define total dose thresholds and threshold effects for several NO(*)-induced toxicity...

S 457 PNH, the development of aplastic anemia, and the finding of leukocyte and platelet abnormalities in this disease imply that this condition is not exclusively related to the red blood cells. Three cases from the Department of Hematology, University of S#{227}o Paulo Medical School are presented. After an initial phase, suggestive of aplastic anemia in cases 1 and 3, and of idiopathic acqui...