Time-kill curves were used to assess the relative in vitro efficacy of the early interaction of three semisynthetic penicillins with two aminoglycosides against 48 Enterobacteriaceae strains. The most efficacious combinations were piperacillin plus amikacin, which demonstrated synergism (greater than or equal to 2 logs of increased kill after 7 h of incubation) against 43 of 48 (90%) strains, a...

The activity of nalidixic acid combined with each of 10 other antimicrobial agents on 95 strains of Enterobacteriaceae was studied. Synergism was found less often than antagonism, and the commonest outcome was indifference. Combinations of nalidixic acid with kanamycin, gentamicin, or colistin were more often synergistic than antagonistic, whereas with the other antibiotics the combination was ...

Infant rats with bacteremia and meningitis induced by ampicillin-resistant Haemophilus influenzae type b were treated with ampicillin and nafcillin, alone or in combination. Neither ampicillin alone (in 19 animals) nor nafcillin alone (in 20 animals) sterilized the blood or cerebrospinal fluid of any treated infant rat. When the combination of ampicillin and nafcillin was used, blood cultures w...

Fields such as genomics and systems biology are built on the synergism between computational and experimental techniques. This type of synergism is especially important in accomplishing goals like identifying all functional transcription factor binding sites in vertebrate genomes. Precise detection of these elements is a prerequisite to deciphering the complex regulatory networks that direct ti...

BETTINA M. FROST, MARY E. VALIANT and EUGENE L. DULANEY Merck Institute for Therapeutic Research Rahway, New Jersey, 07065, U.S.A. (Received for publication May 26, 1979) Efrotomycin1) is a narrow spectrum antibiotic which is most active in vitro against representative species of Pasteurella, Moraxella and Corynebacterium2) . The in vivo activity, however, is much better than one would expect f...