In Europe, ultraviolet (UV) B phototherapy is being increasingly used for the treatment of skin disease. While this is in part due to an increased awareness of the cancer risks of photochemotherapy (PUVA) there is also evidence that a ‘new’ UVB phototherapy source (TL-01) is more effective than conventional broadband UVB sources, and is possibly as effective as PUVA. A working party of the Brit...

Phototherapy is a second-line treatment modality for the most common dermatoses that is safe and effective. Most phototherapy regimens denote the use of ultraviolet (UV) radiation of different wavelengths in the management of several dermatoses. Currently, irradiations with broadband UVB (290-320 nm), narrowband UVB (311-313 nm), 308 nm excimer laser, UVA 1 (340-400 nm), UVA with psoralen (PUVA...

OBJECTIVE To assess the severity of psoriasis over time. DESIGN We analyzed the results of structured dermatologic examinations administered over a 20-year period beginning 10 years after study enrollment. SETTING The PUVA [psoralen-UV-A] Follow-up Study, which is a prospective cohort study. PATIENTS The analyses were restricted to 815 patients (83.2% of those eligible) who underwent at l...

BACKGROUND Limited data exist in the literature concerning the characteristics of erythema following psoralen UV-A (PUVA) treatment using topical methoxsalen. To optimize the phototherapeutic regimen and reduce short- and long-term risks, knowledge of such basic information is essential. OBSERVATIONS The characteristics of PUVA erythema following 15- and 5-minute immersion in methoxsalen was ...

BACKGROUND Smooth muscle cell proliferation plays a major role in the genesis of restenosis after angioplasty or vascular injury. Although the effects of arterial exposure to high-energy radiation sources such as laser have been investigated in detail, the effects on vascular cells of low-intensity radiant energy in combination with photoactive agents have not been extensively characterized. Ps...

Biologic therapies improved dramatically the outcome of psoriatic arthritis and moderate to severe chronic plaque psoriasis. Anti-TNF agents were developed approximately one decade ago by rheumatologists and today represent one of the most effective classes of drugs in severe psoriasis resistant to 2 out of 3 "classic" systemic therapies (methotrexate, cyclosporine, and PUVA). Recent studies on...

INTRODUCTION Phototherapy is effective for mycosis fungoides. Narrow band UVB (UVB1) therapy is being used as an alternative to PUVA therapy for its efficacy and less adverse events. The objective of the study was to determine the efficacy of narrow band UVB therapy in early stage mycosis fungoides. METHODS It is a retrospective study of 23 patients with stage IB mycosis fungoides that have r...