As a natural development of a long-standing interest in uterine contractility several investigations of the effects of drugs on the uterus have been undertaken in the Nuffield Department of Obstetrics and Gynacology in recent years. These studies form a basis for a review of some recent work of clinical' importance concerning the behaviour of the uterus under the influence of various therapeuti...

This article, the first in a series of three, introduces cancer immunology, cancer immunotherapy strategies, and the classes of anticancer therapeutic agents.

Technical limitations, logistic challenges, and ethical constraints no longer provide excuses for not conducting well-designed studies of therapeutic agents in children. In fact, to not do so is difficult to defend ethically. Clinical trials in children are feasible and essential for safe and effective use of medications in children. The time is long past when drugs with therapeutic potential i...

New therapeutic agents marketed in the first half of 2009: Part 1

saffron, the dried red-orange stigmas of crocus sativus l, has been known as a flavoring agent, food coloring and traditional herbal medicine. pharmacological effects of saffron are mainly attributed to crocin, crocetin, picrocrocin and safranal. these components especially crocin, have significant effects including antidepressant and anticonvulsant, analgesic, anti-cancer and other therapeutic...

Background: Due to interesting tumor imaging properties of bis-thiosemicarbazones, [103Pd]-di-acetyl-bis (N4-methylthiosemicarbazone) ([103Pd] ATSM2) was prepared according to the analogy of radio copper homologues. Materials and Methods: Palladium-103 (T1/2=16.96 d) was produced via the 103Rh (p,n) 103Pd nuclear reaction with proton energy 18 MeV. The final activity was eluted in form of Pd ...

Conventional therapeutic agents have displayed significant shortcomings. For this reason, important achievements have effectively made in biotechnology for delivering the therapeutic agents to the site of action, and diminish side effects. Polymeric carriers, micelles, dendrimers, liposomes, solid lipid carriers, gold carriers, viral carriers, nanotubes and magnetic carriers incorporating cytot...

A 14 years old girl, with documented Ewing's sarcoma, was treated by both chemotherapy and surgery. An initial bone scan (TC-99m-MI)I*) did not reveal a renal lesion. However, following therapeutic irradiation, there was retention of the bone imaging agent in a portion of the kidney that had been included in the radiation field. This reflected the effects of radiation related parenchymal ...

Today, researchers are constantly developing new nanomaterials, nanodevices, and nanoparticles to meet unmet needs in the delivery of therapeutic agents and imaging agents for cancer therapy and diagnosis, respectively. Of particular interest here are lipid-based nanoparticles (LNPs) that are genuine particles (approximately 100 nm in dimension) assembled from varieties of lipid and other chemi...