نتایج جستجو برای: tim 1
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*Christoph Kleinschnitz,1 *Peter Kraft,1 Angela Dreykluft,1 Ina Hagedorn,2 Kerstin Göbel,3 Michael K. Schuhmann,3 Friederike Langhauser,1 Xavier Helluy,4 Tobias Schwarz,1 Stefan Bittner,3 Christian T. Mayer,5 Marc Brede,6 Csanad Varallyay,7 Mirko Pham,8 Martin Bendszus,8 Peter Jakob,4 Tim Magnus,9 Sven G. Meuth,3,10 Yoichiro Iwakura,11 Alma Zernecke,2 Tim Sparwasser,5 Bernhard Nieswandt,2 Guido...
این مقاله بر اساس انجام یک مطالعهی توصیفی تهیه شده است و طی آن یکپارچگی بین مدیریت کیفیت جامع (TQMو مدیریت تکنولوژی و تحقیق و توسعه (TIM)، در راستای پیشبینی عملکردهای سازمان در حوزههای کیفیت و نوآوری، مورد آزمون قرار میگیرد. این مطالعه رابطهی بین TQM و TIM را با تأکید بر دو موضوع مهم زیر به انجام می-رساند:نخست یکپارچگی بین TQM و TIM از طریق بررسی شکاف بین این دو بخش مهم، که در سازمان...
UNLABELLED The interaction between T cell immunoglobulin- and mucin-domain-containing molecule (Tim-3) expressed on T helper 1 (Th1) cells, and its ligand, galectin-9, negatively regulates Th1-mediated immune responses. However, it is poorly understood if and how the Tim-3/galectin-9 signaling pathway is involved in immune escape in patients with hepatocellular carcinoma (HCC). Here we studied ...
Tim-3 was initially identified on activated Th1, Th17, and Tc1 cells and induces T cell death or exhaustion after binding to its ligand, Gal-9. The observed relationship between dysregulated Tim-3 expression on T cells and the progression of many clinical diseases has identified this molecule as an important target for intervention in adaptive immunity. Recent data have shown that it also plays...
Traceability usage within different projects is as manifold as the domains in which traceability is applied. A traceability information model (TIM) describes the traceability for a project. A basic TIM consists of at least two types of artifacts and a traceability relation between these artifacts [3]. One of the open traceability challenges is the traceability adaptation during usage [1]. The T...
Aligned carbon nanotube (CNT) arrays were fabricated from a multilayer catalyst configuration by microwave plasma-enhanced chemical vapor deposition (PECVD). The effects of the thickness and annealing of the aluminum layer on the CNT synthesis and thermal performance were investigated. An experimental study of thermal resistance across the CNT array interface using the modified ASTM D5470 stand...
The transcription/translation feedback loop-based molecular oscillator underlying the generation of circadian gene expression is preserved in almost all organisms. Interestingly, the animal circadian clock proteins CRYPTOCHROME (CRY), PERIOD (PER) and TIMELESS (TIM) are strongly conserved at the amino acid level through evolution. Within this evolutionary frame, TIM represents a fascinating puz...
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