Pactamycin, although putatively touted as a potent antitumor agent, has never been used as an anticancer drug due to its high cytotoxicity. In this study, we characterized the effects of two novel biosynthetically engineered analogs of pactamycin, de-6MSA-7-demethyl-7-deoxypactamycin (TM-025) and 7-demethyl-7-deoxypactamycin (TM-026), in head and neck squamous cell carcinoma (HNSCC) cell lines ...

Histomoniasis is a disease of turkeys on litter or range caused by the fragile protozoan Histomonas meleagridis, a parasite of worms, primarily spread in faeces, in Heterakis gallinarum (caecal worm) eggs or in Eisenia foetita (earthworms). Symptoms include poor feed conversion ratio (FCR), decreased body weight (BW), diarrhea, caecal and liver lesions, darkening of the facial regions and somet...

Technology now at hand can integrate all kinds of digital information for individuals, groups, and organizations so their information usefully links together. iInfoTM information integration works by making connections including examples like the following:  A statistical connection between “being in a traffic jam” and “driving in downtown Trenton between 5PM and 6PM on a weekday.”  A termino...

Image misregistration has become one of the significant bottlenecks for improving the accuracy of multisource data analysis, such as data fusion and change detection. In this paper, the effects of misregistration on the accuracy of remotely sensed change detection were systematically investigated and quantitatively evaluated. This simulation research focused on two interconnected components. In...

Seagrass distribution is a very important index for costal management and protection. Seagrass distribution changes can be used as indexes to analyze the reasons for the changes. In this paper, in situ hyperspectral observation and satellite images of QuickBird, CBERS (China Brazil Earth Resources Satellite data) and Landsat data were used to retrieve bio-optical models and seagrass (Enhalus ac...

Remote sensing using Landsat Thematic Mapper (TM) satellite imagery is increasingly used for mapping wildland fire burned area and burn severity, owing to its frequency of collection, relatively high resolution, and availability free of charge. However, rapid response of vegetation following fire and frequent cloud cover pose challenges to this approach in the southeastern US. We assessed these...

The first demonstration of blue upconversion fiber lasers in Tm-ZBLAN has generated considerable interest among laser scientists looking for all-solid-state visible sources. Although initial experiments have shown a large conversion efficiency, a good spatial beam quality and an overall simplicity of the approach, these sources have not yet appeared on the market. In an attempt to reproduce the...