We examine the progress that has been made towards the development of topical treatments for premature ejaculation (PE). Although generally regarded as one of the most common male sexual problems, the lack of approved pharmacological agents for PE means that treatment options are limited to behavioural therapy, where available, and the use of drugs 'off-label'. There are various theories on the...

Purpose: To evaluate the effect of a topical application of a cream formulation containing extract of Acacia nilotica bark extract on human cheek skin texture. Methods: A cream containing 3 % concentrated extract of Acacia nilotica bark was developed by entrapping the extract in the internal aqueous phase of the cream having strong antioxidant activity. A similar cream but without the extract w...

BACKGROUND There are 3 new topical treatments for herpes labialis that have either been approved by the US Food and Drug Administration (penciclovir cream [Denavir] and n-docosanol cream [Abreva]) or recently undergone extensive clinical evaluation (acyclovir cream). The relative efficacy of these products is unknown. OBJECTIVE To compare the efficacy of penciclovir cream, acyclovir cream, n-...

Background and objectives: Skin hyperpigmentation usually indicates an increase in production and accumulation of melanin. Hyperpigmentary disorders are characterized by the appearance of melasma, freckles and lentigo on the skin surface which can cause psychological disturbances. Herbal products could be extensively preferable due to their widespread accessibility and the vast...

Objective: Treatment of mood and behavioral symptoms in geriatric patients with advanced dementia may be impeded by poor compliance with oral medications. Pluronic lecithin organogel (PLO) is a compounding substrate that can be used for the topical administration of psychotropic medications. Methods: Charts of patients treated with psychotropic medications compounded with PLO cream were reviewe...

Background: Melasma is a common acquired skin disorder that presents as bilateral, blotchy, brownish facial pigmentation due to dysfunction in melanogenesis. It most people who tans easily or have naturally brown (Fitzpatrick’s phototypes III, IV). Although several treatments are currently used, it remains great challenge. Aim: This study aims compare the efficacy of intradermal injection trane...

Background: The mastic extract of Pistacia species can be considered as a natural herbal source in the pharmaceutical industry. Objective: The purpose of this study was to evaluate the effectiveness of Pistacia atlantica mastic on wound healing, oxidative and blood biochemical parameters. Methods: Topical cream and oral suspension was made of the mastic of P. atlantica, after preparing hydr...