A new variable selection wrapper method named the Monte Carlo variable selection (MCVS) method was developed utilizing the framework of the Monte Carlo cross-validation (MCCV) approach. The MCVS method reports the variable selection results in the most conventional and common measure of statistical hypothesis testing, the P-values, thus allowing for a clear and simple statistical interpretation...

Com o propósito de aumentar a atividade anticâncer demonstrada anteriormente pelas 1-fenilssubstituído-3-(2-tioxo-1,3,4-oxadiazol-5-il) b-carbolinas 1a-c, neste trabalho foram realizadas a síntese e a avaliação in vitro da atividade antitumoral de novas bases de Mannich 2-7(a-c), derivadas da introdução de diferentes grupos alquilamino(metil) na unidade 1,3,4-oxadiazol de 1a-c. Os derivados 1a-...

JDTic analogues 4-15 which have the hydroxyl groups replaced with other groups were synthesized and their in vitro efficacy at the μ, δ, and κ opioid receptors determined and compared to JDTic using [(35)S]GTPγS assays. Compounds 4, 5, 6, 13, 14, and 15 had Ke = 0.024, 0.01, 0.039, 0.02, 0.11, and 0.041 nM compared to the Ke = 0.02 nM for JDTic at the κ receptor and were highly selective for th...

The development of organelle-specific fluorescent probes has been impeded by the absence a comprehensive understanding relationship between physicochemical properties and their selectivity towards specific organelles. Although few machine learning models have suggested several parameters that control target organelle attempted to predict organelles, they challenged low accuracy limited range ap...

This paper reports the synthesis and evaluation of some new 2-(benzimidazol-2-yl)-3-(4-(4-substitutedpiperazin-1-yl)phenyl)propanenitrile derivatives for their in vitro antimycobacterial activities against Mycobacterium tuberculosis H37Rv. Among them, 4c was found to be most active compound with MIC 1.56 μg/mL M. tuberculosis. In addition, showed 2.1 log reduction nutrient starved which is more...

Penelitian ini membahas pentingnya pengelolaan sampah dalam menjaga keseimbangan antara lingkungan dan kepadatan penduduk di perkotaan. Sampah merupakan masalah yang memerlukan perhatian serius dari pemerintah masyarakat. Pemerintah Kota Magelang telah menghadapi kendala terkait ruang penampungan jarak TPS TPA. Untuk mengatasi ini, dibuatlah sistem monitoring volume sebagai platform efisien unt...

The piperazine derivatives have been shown to inhibit human acetylcholinesterase. Virtual screening by molecular docking of piperazine derivatives 1-(1,4-benzodioxane-2-carbonyl) piperazine (K), 4-(4-methyl)-benzenesulfonyl-1-(1,4-benzodioxane-2-carbonyl) piperazine (S1), and 4-(4-chloro)-benzenesulfonyl-1-(1,4-benzodioxane-2-carbonyl) piperazine (S3) has been shown to bind at peripheral anioni...

OBJECTIVES To select a group of useful serum markers in renal cell carcinoma (RCC) with investigational purpose in future. MATERIAL AND METHODS Periodic determination in serum of 21 RCC patients of the following markers: EGR, RPC, hemogram and leucocyte differential count (LDC), standard biochemist parameters, beta-2 microglobuline, CEA, CA 12.5, CA 50, CA 15.3, ferritin, interleukin-6, serum...