Drug-induced cholestasis is the main type of liver disorder accompanied by high morbidity and mortality. Evidence for the role of hepatobiliary pumps in the cholestasis patho-mechanism is constantly increasing. Recognition of the interactions of chemical agents with these transporters at the initial phases of drug discovery can help develop new drug candidates with low cholestasis potential. Th...

Nowadays, the globalization is one of the most significant phenomena of contemporary life. There are many debates about the real meaning of the globalization, its roots, effects and future. Among the most important aspects of the globalization is surely the global transportation system. In this framework it is clear how the availability of an advanced integrated transportation system, for movin...

Agmatine is a biogenic amine with the capacity to regulate a number of nonreceptor-mediated functions in mammalian cells, including intracellular polyamine content and nitric oxide generation. We observed avid incorporation of agmatine into several mammalian cell lines and herein characterize agmatine transport in mammalian cells. In transformed NIH/3T3 cells, agmatine uptake is energy dependen...

The transport-ticket program was disposed at law in Brazil at end of 1985 but became compulsory for the companies only at the end of 1987.The program appeared to decrease the social tension at big cities caused by the poor functioning of the urban collective transport system, with crowd revolts and depredations. The program intends to facilitate the modernization and maintenance of quality o f ...

background: transport of the critically ill patient is potentially risky and the transport team should be careful in making decision and be prepared to deal with them in any condition. our physicians are not qualified in safe transport. we want to evaluate the effect of small group teaching method for promotion of physicians' skills in transport of critically ill patients. methods: in an interv...

Background & objectives: The urban rail transport network is always at risk due to its special conditions. Many cases indicate the existence of threatening and risk factors for human societies in urban rail transportation systems. Therefore, in this study, with the aim of identifying and prioritizing the risks of urban rail transportation networks in order to increase resilience is on the agend...