This paper discusses the development of a new method for the automatic segmentation of anatomical structures from volumetric medical images. Driving application is the segmentation of 3-D tumor structures from magnetic resonance images (MRI), which is known to be a very challenging segmentation problem due to the variability of tumor geometry and intensity patterns. Level set evolution combinin...

PURPOSE Despite lymphocyte infiltration of tumors and the activation of tumor-draining lymph nodes, malignant tumors are able to "escape" from both innate and adaptive immune responses. For immunotherapy to be successful, it must reverse these escape mechanisms, which necessitates explicit and tumor-specific elucidation of tumor escape strategies. RESEARCH DESIGN To identify relevant escape m...

PURPOSE To compare "standardization," "Gaussian normalization," and "Z-score normalization" intensity transformation techniques in dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) estimates of cerebral blood volume (CBV) in human gliomas. DSC-MRI is a well-established biomarker for CBV in brain tumors; however, DSC-MRI estimates of CBV are semiquantitative. The use of image ...

Abstract Medulloblastoma (MB) is a primary central nervous system tumor and the most common malignant brain cancer among children. Neuropathologists perform microscopic inspection of histopathological tissue slides under microscope to assess severity tumor. This timeconsuming task often infused with observer variability. Recently, pre-trained convolutional neural networks (CNN) have shown promi...

The potential of a spheroid tumor model composed of cells in different proliferative and metabolic states for the development of new anticancer strategies has been amply demonstrated. However, there is little or no information in the literature on the problems of reproducibility of data originating from experiments using 3D models. Our analyses, carried out using a novel open source software ca...

BACKGROUND After experimental carotid sinus denervation in animals, blood pressure (BP) level and variability increase markedly but normalize to preoperative levels within 10 to 14 days. We investigated the course of arterial BP level and variability after bilateral denervation of the carotid sinus baroreceptors in humans. METHODS AND RESULTS We studied 4 women (age 41 to 63 years) who were r...

BACKGROUND "Waterfall plots" are used to describe changes in tumor size observed in clinical studies. Here we assess criteria for generation of waterfall plots and the impact of measurement error in generating them. METHODS We reviewed published waterfall plots to investigate variability in criteria used to define them. We then compared waterfall plots generated by different observers for 24 ...

endocrine tumors of the pancreas (islet-cell tumors) are rare with neuroendocrine origin. the patient was a 41- year- old man, admitted with chief complains of epigastric mass feeling, dull abdominal pain, lack of appetite and weight loss up to 2-3 kg since 6 months ago. in physical examination, a mass was detected in epigaster and left upper quadrant (luq). in abdominal x-ray, a calcified mass...

background: solitary fibrous tumor (sft) is a mesenchymal tumor which is most commonly seen in the pleura; however it can be seen in other organs such as the meninge, gastrointestinal tract, soft tissue, bone, and skin. sft should be differentiated from other mesenchymal tumors in these organs. immunohistochemistry plays a pivotal role for the histopathologic diagnosis of this tumor. currently,...