The functions of the lower urinary tract to store and eliminate urine are regulated by complex neural pathways that coordinate activity smooth striated muscles bladder, urethra, urethral sphincters. 1 de Groat W.C. Yoshimura N. Afferent nerve regulation bladder function in health disease. Handb Exp Pharmacol. 2009; 194: 91-138 Crossref PubMed Scopus (195) Google Scholar Besides control central ...

Urolithiasis (URL) is a common urological disease that often appears in the population, has high recurrent rate and significant impact on social status of population. Almost half patients with URL are people ureteric stones, 95% which have secondary genesis. The main methods treatment such extracorporeal shock-wave lithotripsy (ESWL) ureterolithotripsy (URS). It important these cases to determi...

Here we describe the effect of colistin on the barrier function of the mammalian urinary bladder epithelium. Addition of colistin to the mucosal solution of the rabbit urinary bladder epithelium (urothelium) resulted in an increase in the transepithelial conductance. The magnitude of the increase in transepithelial conductance was dependent on the membrane voltage, concentration of colistin, an...

Claudin (Cld)-4 is one of the dominant Clds expressed in the kidney and urinary tract, including selective segments of renal nephrons and the entire urothelium from the pelvis to the bladder. We generated Cldn4(-/-) mice and found that these mice had increased mortality due to hydronephrosis of relatively late onset. While the renal nephrons of Cldn4(-/-) mice showed a concomitant diminution of...

Although the cellular turnover of resting urothelium is very low, its regenerative capacity is known to be outstanding. In organotypic mouse urothelial cultures closely mimicking the differentiation and multilayering of normal urothelium, we examined the cell biological mechanisms underlying urothelial regeneration and the specific role of growth factors and several extracellular matrix (ECM) c...

OBJECTIVE To investigate the changes including expression and localization of 2 potassium channels, renal outer medullary K+ channel (ROMK) and voltage-gated K+ channel 7.1 (KCNQ1), after increased urinary potassium leakage in patients with interstitial cystitis/painful bladder syndrome (IC/PBS). MATERIALS AND METHODS The study group included 24 patients with IC/PBS and a control group consis...

During urinary tract infection (UTI), the second most common bacterial infection, dynamic interactions take place between uropathogenic E. coli (UPEC) and host urothelial cells. While significant strides have been made in the identification of the virulence factors of UPEC, our understanding of how the urothelial cells mobilize innate defenses against the invading UPEC remains rudimentary. Here...

UNLABELLED To evaluate the expression of sphingosine kinase 1 (SPK1) in the bladder wall in patients with neurogenic lower urinary tract dysfunction and its association with clinical, urodynamic and pathological features. MATERIALS AND METHODS The expression of SPK1 was studied in bladder wall specimens obtained from cystectomy using immunohistochemistry in ten patients with spinal cord injur...

Twenty-two continuous cell lines derived from normal and neoplastic urothelium, maintained under identical culture conditions, were characterized in terms of isozyme phenotype, tumorigenicity, and xenograft morphology following xenotransplantation to nude mice, cytological appearance, in vitro growth rate, labelling index, and colony-forming efficiency, in parallel with separate studies of in v...