OBJECTIVE Intensive chemotherapy targeting plasma cell dyscrasia has been recently employed for the treatment of primary systemic AL amyloidosis. We prospectively studied the clinical usefulness of cyclic VAD (vincristine, doxorubicin and dexamethasone) in patients with primary systemic AL amyloidosis who were ineligible for high-dose melphalan with autologous stem cell support. PATIENTS AND ...

Ventricular assist devices (VADs) have been shown to offer a significant survival benefit over medical therapy in patients with advanced heart failure. Despite significant advances in device technology and surgical technique, VAD-specific infections still remain among the most common causes of morbidity and mortality in patients with VADs. VAD-specific infections may involve the driveline exit ...

OBJECTIVE to determine whether functional changes in the vasculature differ between Alzheimer's disease (AD) and vascular dementia (VAD). DESIGN we determined vascular stiffness in patients with a clinical and radiological diagnosis of either AD or VAD and compared them to normal age- and sex-matched controls. METHODS In all, 16 patients with late onset AD, 13 subjects with VAD and 16 age- ...

Since 2008, interview-style speech has become an important part of the NIST Speaker Recognition Evaluations (SREs). Unlike telephone speech, interview speech has lower signal-to-noise ratio, which necessitates robust voice activity detectors (VADs). This paper highlights the characteristics of interview speech files in NIST SREs and discusses the difficulties in performing speech/non-speech seg...

We study the problem of detecting and counting simultaneous, overlapping speakers in a multichannel, distant-microphone scenario. Focusing on supervised learning approach, we treat Voice Activity Detection (VAD), Overlapped Speech (OSD), joint VAD OSD (VAD+OSD) speaker unified way, as instances general Counting (OSDC) multi-class problem. consider Temporal Convolutional Network (TCN) Transforme...

It was reported by authors that the prevalence of clinical vitamin A deficiency (VAD) has declined considerably in India, as compared to previous years [2]. However, they found a high prevalence of blood vitamin A deficiency (<20 μg/dL), a criteria for sub-clinical VAD [3]. In their data, 61% preschool children had subclinical VAD, and with this criterion, a public health problem was diagnosed ...

In vitro statins induce apoptosis in myeloma and lymphoma cells in a dose-and time-dependent way. In combination with dexamethasone and doxorubicin, statins have a chemo-sensitizing effect. Twenty-eight patients with relapsed myeloma or lymphoma were treated with a dose-escalating regimen of simvastatin for 7 days followed by VAD in myeloma patients and CHOP in lymphoma patients. The maximum to...

In order to prevent the onset of vascular dementia (VaD) in aging individuals, it is critical to detect clinically relevant vascular and systemic pathophysiological changes to signal the onset of its preceding prodromal stages. Identifying behavioral and neurobiological markers that are highly sensitive to VaD classification vs. other dementias is likely to assist in developing novel preventive...

A total of 2,905 children between 6 and 71 months of age were selected using a 2 stage stratified sampling method and screened for xerophthalmia using World Health Organisation (WHO) criteria and vitamin a deficiency (VAD) using serum retinol < 20 μg/dl (low/marginal). Only 33 cases of xerophthalmia were seen representing a national prevalence of 1.1%. Only 8 children presented with Bitot’s spo...

We investigated the effects of dietary supplementation of zinc (Zn) with or without vitamin A (Vit. A), to elucidate any cross activity between the two micronutrients, on memory and nerve growth factor (NGF) production in ddY male mice depleted for the two elements. After 3 mo-feeding with a Zn and Vit. A deficient (VAD) diet, mice were divided into three groups and replenished with normal Zn w...