نتایج جستجو برای: vad regimen
تعداد نتایج: 48646 فیلتر نتایج به سال:
introduction: the aim of our study is evaluation of response rate of vad (vincristin, adriamycin and dexamethason) regimen as initial treatment in 40 new cases of multiple myeloma. this is the first systemic and classic report of vad regimen in iranian population. methods: all patients with at least stage 2 multiple myeloma or progressive disease after physical examination, para- clinical profi...
BACKGROUND AND OBJECTIVES Standard treatment for patients with multiple myeloma is debulking chemotherapy with non-alkylating agents followed by a regimen to mobilize peripheral blood stem cells (PBSC) and the transplantation of the mobilized, autologous PBSC. The aim of this study was to evaluate the efficacy of a new regimen and compare it with that of a previous regimen. DESIGN AND METHODS...
Mr. F received several different treatment regimens for MM. He required a cardioprotectant, dexrazoxane, to continue treatment with the VAD regimen. He received interferon, high-dose chemotherapy with tandem stem cell transplants, and newer agents used in the treatment of MM, such as thalidomide and topotecan. However, as illustrated by Mr. F's case study, MM remains an incurable disease despit...
UNLABELLED Background There is currently no international consensus for first-line treatment (prior to autologous stem cell transplantation) in mantle cell lymphoma patients. Here, we investigated the efficacy and tolerance of VAD associated with chlorambucil (VAD+C) and rituximab or not before autologous stem cell transplantation. DESIGN AND METHODS Between 1996 and 2005, 113 previously untr...
We examined the feasibility of achieving a rapid response in patients with previously untreated multiple myeloma by administering vincristine 0.4 mg and doxorubicin 9 mg/m2 as a rapid intravenous infusion for 4 d together with intermittent high-dose dexamethasone 40 mg (VAD) for remission induction treatment in patients who were scheduled to receive high-dose therapy. 139 patients (86 male, 53 ...
The aim of the present study was to compare thalidomide-dexamethasone (Thal-Dex) and vincristine-doxorubicin-dexamethasone (VAD) as primary therapy in preparation for autologous peripheral blood stem-cell (PBSC) transplantation for multiple myeloma (MM). For this purpose, we performed a retrospective matched case-control analysis of 200 patients who entered 2 consecutive studies from 1996 to 20...
The aim of the present study was to compare thalidomide-dexamethasone (Thal-Dex) and vincristine-doxorubicindexamethasone (VAD) as primary therapy in preparation for autologous peripheral blood stem-cell (PBSC) transplantation for multiple myeloma (MM). For this purpose, we performed a retrospective matched case-control analysis of 200 patients who entered 2 consecutive studies from 1996 to 200...
BACKGROUND High-dose chemotherapy with autologous stem cell transplantation after initial cytoreductive chemotherapy with the combination vincristine, doxorubicin and dexamethasone (VAD) is considered an effective therapy for many patients with newly diagnosed, symptomatic multiple myeloma. Response to initial cytoreductive chemotherapy is important for the long-term outcome of such patients. T...
We introduce a Lie algebra of initial terms of logarithmic vector fields along a hypersurface singularity. Extending the formal structure theorem in [GS06, Thm. 5.4], we show that the completely reducible part of its linear projection lifts formally to a linear Lie algebra of logarithmic vector fields. For quasihomogeneous singularities, we prove convergence of this linearization. We relate our...
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