Patients implanted with mechanical heart valves (MHV) or with ventricular assist devices that use MHV require mandatory lifelong anticoagulation for secondary stroke prevention. We recently developed a novel Device Thrombogenicity Emulator (DTE) methodology that interfaces numerical and experimental approaches to optimize the thrombogenic performance of the device and reduce the bleeding risk a...

During valvulogenesis, globular endocardial cushions elongate and remodel into highly organized thin fibrous leaflets. Proper regulation of this dynamic process is essential to maintain unidirectional blood flow as the embryonic heart matures. In this study, we tested how mechanosensitive small GTPases, RhoA and Rac1, coordinate atrioventricular valve (AV) differentiation and morphogenesis. Rho...

the history of closed mitral valve comissurotomy (cmvc) and its indication is discussed in this article. however many of the patients undergo (ptmc) these days as a new procedure and of course more effective and easier way whenever is indicated, yet, (cmcv) should be considered as a simple, and effective surgery when indicated, especialy in third world countries in which economical, social and ...

Herceptin and its pH stressed samples were quantified by measuring UV 280 absorption. Figure 4 is the overlay absorption spectra of four samples. Aggregations around 25% for pH 0.5, 6% for pH 1.5 and 0% for pH 2.5 were observed. Figure 3. a). Flexible three valve configuration for carrying out different experimental tasks simultaneously in the cooling chamber, b). NCS-3500RS with binary rapid s...

IMPORTANCE The stairstep graft is a novel method to modify the lateral anchoring point of lateral grafts for nasal valve correction. OBSERVATIONS Eight consecutive patients with a diagnosis of nasal valve collapse were included in the study. The novel method of stairstep grafts was performed to reinforce the lateral crus and to widen the nasal valve. Postoperative evaluations were performed b...

Valve positioner is the core component of pneumatic control valve. A new software and hardware design scheme intelligent valve presented in this paper. The circuit composition each part introduced part. Based on it, a solution to realize HART ‘multi-point’ communication proposed research. In design, novel combined PID algorithm solve nonlinear problem caused by friction between stem packing dur...

in order to develop more efficient engines, it is essential to optimize the lubrication circuit of the power train systems. in this paper, during an engine design and development process, a network analysis of the engine lubrication system is described in detail. two elements have been added to the lubrication circuit in the modified engine. these elements are hydraulic lifters and an anti-drai...

In this research, softening and ratcheting behaviors of Ck20 alloy steel cylindrical shells were studied under displacement-control and force-control cyclic axial loading and the behavior of hysteresis curves of specimens was also investigated. Experimental tests were performed by a servo-hydraulic INSTRON 8802 machine. The mechanical properties of specimens were determined according to ASTM E8...