INTRODUCTION Hepatitis C virus reinfection occurs universally after liver transplantation with accelerated cirrhosis rates of up to 30% within 5 years after liver transplantation. Management of hepatitis C virus reinfection is complicated by drug interactions and pre-treatment. Dual antiviral therapy with pegylated interferon and ribavirin only reaches sustained virological response rates of ap...

The development of antiviral drug resistance is an important problem in the treatment of human immunodeficiency virus type 1 (HIV-1) infection. Potent antiretroviral therapy is currently used for treatment, and typically consists of at least two reverse transcriptase (RT) inhibitors. We have previously reported that both drugs and drug-resistant RT mutants can increase virus mutation frequencie...

background: our aim was to detect the rate of toxoplasma gondii infections and the coinfections in childbearing age women in turkey accompanying using seroprevalence data from a multicenter hospital setting. methods: overal, 17751 childbearing age women through 16-45 years were included to the study between 2004 and 2010. the clinical samples of the patients were collected from 16 hospitals and...

Abstract Background and Aims: The Hepatitis C Virus (HCV) is essentially hepatotropic but virus compartment has also been found in other important extra hepatic sites. Detection of HCV RNA in extra hepatic reservoirs such as peripheral blood mononuclear cells (PBMCs) is important for determining of disease progression and effective treatment. The present study aimed to determine of differe...

Lithium carbonate inhibited plaque formation of herpes simplex virus types 1 and 2 in rabbit kidney and Vero cells (50% effective dose, 435.5 to 490 micrograms/ml). Plasma lithium levels of 67 to 134 micrograms/ml were achieved by oral therapy in rabbits. However, neither ocular virus shedding nor virus-positive trigeminal ganglia were reduced after intentional reactivation of latent herpes sim...

background many types of cardiovascular complications such as; cardiac arrhythmias, impaired cardiac function, myocardial ischemia and decreased left ventricular function, have been attributed to interferon therapy. objectives the aim of this study was to evaluate the effects of combination therapy pegylated interferon and ribavirin on left ventricular systolic and diastolic functions in patien...

Received: October 02, 2015; Accepted: October 20, 2015; Published: October 23, 2015 Abbreviations: PML: Progressive Multifocal Leukoencephalopathy; JCV: John Cunningham Virus; AIDS: Acquired Immune Deficiency Syndrome; CSF: Cerebrospinal Fluid; HIV: Human Immuno deficiency Virus; HSV: Herpes Simplex Virus; VZV: Varicella Zoster Virus; CMV: Cytomegalovirus; ADC: Apparent Diffusion Coefficient; S...

The initiation of drug therapy or the addition of a new drug to preexisting therapy can have a significant impact on human immunodeficiency virus type 1 (HIV-1) populations within a person. Drug therapy directed at reverse transcriptase and protease can result in dramatic decreases in virus load, causing a contraction in the virus population that represents a potential genetic bottleneck as a s...