Chaste is an open-source C++ library for computational biology that has well-developed cardiac electrophysiology tissue simulation support. In this paper, we introduce the features available for performing cardiac electrophysiology action potential simulations using a wide range of models from the Physiome repository. The mathematics of the models are described in CellML, with units for all qua...

Given the ecological and epidemiological specialization of Hyalesthes obsoletus, principle vector ‘Candidatus Phytoplasma solani’, primary objective this study was to develop molecular tools for discriminating three host plant associations populations: (i) Convolvulus arvensis–Urtica dioica (Ca–Ud), (ii) Vitex agnus-castus (Vac), (iii) Crepis foetida (Cf). The genetic diversity nearly full-leng...

Classical homeopathy is based on the therapeutic application of highly diluted homeopathic stocks. The indications of such medicines are determined by proving, i.e. by applying the remedies in healthy subjects. However, there are several complex homeopathic medicinal products on the market with approved therapeutic indications. The efficacy of these medicines has been assessed in clinical trial...

Casticin, as a major effective component in Chinese herbal medicine Vitex agnus-castus exhibits an antiinflammatory property to rheumatoid arthritis (RA), while the potential mechanism is unclear. We aim at investigating the mechanism of Casticin on lipopolysaccharides (LPS)-induced fibroblast-like synoviocytes (LiFLSs) inflammation model. Fibroblast-like synoviocytes (FLSs) were treated with 2...

The house fly, Musca domestica, is a very significant pest due to transmitting of various human and animal pathogenic diseases. In a response to environmental threats of chemical insecticides, toxic and biochemical effects of a relatively new plant extracts of willow (Salix aegyptiaca L.) and chasteberry (Vitex agnus-castus L.) comparing with NeemAzal T/S were studied on 3 larval instar of M. d...