نتایج جستجو برای: x chromosome inactivation
تعداد نتایج: 770496 فیلتر نتایج به سال:
In mammals, dosage compensation for X-linked gene products between XX females and XY males is achieved through the transcriptional silencing of one of the two X chromosomes in the developing female embryo (Lyon 1961). This process of X-chromosome inactivation affects more than 1000 genes and is one of the most striking examples of long-range, monoallelic gene silencing in mammals. The choice of...
We have sequenced to high levels of accuracy 714-kb and 233-kb regions of the mouse and bovine X-inactivation centers (Xic), respectively, centered on the Xist gene. This has provided the basis for a fully annotated comparative analysis of the mouse Xic with the 2.3-Mb orthologous region in human and has allowed a three-way species comparison of the core central region, including the Xist gene....
In mammals, X-chromosome dosage compensation is achieved by inactivating one of the two X chromosomes in females. In mice, X inactivation is initially imprinted, with inactivation of the paternal X (Xp) chromosome occurring during preimplantation development. One theory is that the Xp is preinactivated in female embryos, because of its previous silence during meiosis in the male germ line. The ...
X inactivation analysis was performed on normal and hypopigmented skin samples obtained from a female with hypomelanosis of Ito associated with a balanced whole arm X;17 translocation. Severe skewing of X inactivation resulting in inactivity of the intact X was found in blood and cultures of both types of skin, but analysis of DNA prepared directly from hypopigmented skin showed significant ina...
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