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Introduction: X chromosome inactivation (XCI) is a process during which one of the two X chromosomes in female human is silenced leading to equal gene expression with males who have only one X chromosome. Here we have investigated XCI ratio in females with opioid addiction to see whether XCI skewness in women could be a risk factor for opioid addiction. Methods: 30 adult females meeting DS...

introduction: x chromosome inactivation (xci) is a process during which one of the two x chromosomes in female human is silenced leading to equal gene expression with males who have only one x chromosome. here we have investigated xci ratio in females with opioid addiction to see whether xci skewness in women could be a risk factor for opioid addiction. methods: 30 adult females meeting dsm iv ...

x-chromosome inactivation (xci) is a process by which one of the copies of the x chromosome in mammalian female cells is inactivated. the xci causes a balanced x-linked gene quantity between male and females; moreover, it results mosaic females which have paternal active x in some cells and maternal active x in others. cellular mosaicism is a noteworthy phenomenon and lowers the risk of x-linke...

800x600 years ago, it was thought that a genetic component was the fundamental cause of a number retinopathy diseases including age related macular degeneration (amd). since then, information has emerged about novel genes that contribute to various forms of amd and other retinopathies that have been eluding researchers for years. in the genetic sense, only the apoe 2 and 4 genes have been found...

Xist RNA inactivates one mammalian X chromosome (the Xi) by associating with it in cis. The mechanism of this interaction is unresolved. Jeon and Lee (2011) now show that YY1 binds both Xist RNA and DNA, thereby providing a mechanism to anchor Xist to the Xi and facilitate X chromosome inactivation.

The mechanisms by which Xist RNA associates with the X chromosome to mediate alterations in chromatin structure remain mysterious. Recent genome-wide Xist RNA distribution studies suggest that this long noncoding RNA uses 3-dimensional chromosome contacts to move to its sites of action.