Background: Colorectal cancer (CRC) is attributed as one of the most common malignancies worldwide. CD133 molecule, as a pentaspan transmembrane glycoprotein, confers stem cell-related characteristics, including self-renewal and multi-directional differentiation capability. CD133 plays important roles in the progression of CRC by conferring apoptotic resistance and migration ab...

Objective(s):Multidrug resistance (MDR) of cancer cells is a major obstacle to successful chemotherapy. Overexpression of breast cancer resistance protein (BCRP) is one of the major causes of MDR. In addition, it has been shown that PI3K/Akt signaling pathway involves in drug resistance. Therefore, we evaluated the effects of novel approaches including siRNA directed against BCRP and targeted t...

objective(s):multidrug resistance (mdr) of cancer cells is a major obstacle to successful chemotherapy. overexpression of breast cancer resistance protein (bcrp) is one of the major causes of mdr. in addition, it has been shown that pi3k/akt signaling pathway involves in drug resistance. therefore, we evaluated the effects of novel approaches including sirna directed against bcrp and targeted t...

background: introduction of the rna interference (rnai) machinery has guided the researchers to discover the function of essential vital or virulence factor genes in the microorganisms such as fungi. in the filamentous fungus aspergillus nidulans, the gene sidb plays an essential role in septation, conidiation and vegetative hyphal growth. in the present study, we benefited from the rnai strate...

Redox-responsive NPs, delivering DTX in combination with TUBB3 siRNA, increased activity lung cancer (LC) cells. After local administration LC mice models, NPs were retained into the lungs thus exerting high siRNA silencing efficacy.

Small interfering RNAs (siRNA) have enabled novel, specific, and efficient treatment of diseases, including cancer. To obtain sufficient well-controlled intracellular delivery, a drug delivery system is essential. Herein for siRNA, composed cationic biodegradable nanogels, presented. P(DEAEMA-co-HEMA-g-PEGMA) nanogels with varying ratios 2-diethyl aminoethyl methacrylate (DEAEMA) 2-Hydroxyethyl...

* ايجولونكت دهعم – دادغب , ينقتلا ميلعتلا ةئيه / دادغب ** مسق ةسدنه نداعملاو جاتنلاا , ةيجولونكتلا ةعماجلا / دادغب *** ايجولونكتلاو مولعلا ةرازو / دادغب 497 مييقت لكآتلا ةمواقم طاسوا يف ةيتيركنوكلا ةناسرخلا ةيوقت يف مدختسملا ديدحلل ةفلتخم ةيئام بوقعي فسوي ثيل * شابك ةرهزلا دبع لحز ** و حلاص دمحم قفوم *** 2010/12/21 خیرات میدقتلا : 2011/6/2 خیرات لوبقلا : ةصلاخلا ف حيلستلا ديدحل ...