BACKGROUND Schitosomiasis japonica is still a significant public health problem in China. A protective vaccine for human or animal use represents an important strategy for long-term control of this disease. Due to the complex life cycle of schistosomes, different vaccine design approaches may be necessary, including polyvalent subunit vaccines. In this study, we constructed four chimeric protei...

L. Pellissier, Univ. of Fribourg, Unit of Ecology and Evolution, Ch. du Musée 10, CH-1700 Fribourg, Switzerland. – A. Roger, Research station Agroscope ACW Changins-Wädenswil, route de Duillier 50, CH-1260 Nyon, Switzerland. – J. Bilat and S. Rasmann ([email protected]), Dept of Ecology and Evolution, UNIL Sorge, Le Biophore, Univ. of Lausanne, CH-1015 Lausanne, Switzerland. Present address of S...

Columns containing weak cation-exchange stationary phases offer a degree of versatility when used for separation of positively charged proteins. Of particular interest, is the difference in selectivity that can be obtained by adjusting the pH of the mobile phase eluent. We explore the parameters of interest and how these can be changed to optimize the resolution of the compounds of interest usi...

This Application Note describes the development of a method for the separation of four stereoisomers, which were derived from a compound with two steric centers. The method was developed using an Agilent 1260 Infi nity Analytical Supercritical Fluid Chromatography (SFC) solution with Agilent ChemStation Method Scouting Wizard software. The developed method was used to compare the ratio of stere...