نتایج جستجو برای: عوامل انگیزشی erg
تعداد نتایج: 120380 فیلتر نتایج به سال:
The ETS transcription factor ERG plays a central role in definitive hematopoiesis, and its overexpression in acute myeloid leukemia (AML) is associated with a stem cell signature and poor prognosis. Yet how ERG causes leukemia is unclear. Here we show that pan-hematopoietic ERG expression induces an early progenitor myeloid leukemia in transgenic mice. Integrated genome-scale analysis of gene e...
Chromosomal translocations juxtaposing the androgen-responsive TMPRSS2 promoter with the ETS-family transcription factor ERG result in aberrant ERG upregulation in approximately 50% of prostate cancers. Studies to date have shown important roles of ERG in inducing oncogenic properties of prostate cancer. Its molecular mechanisms of action, however, are yet to be fully understood. Here, we repor...
TMPRSS2-ERG junction oncogene is present in more than 50% of patients with prostate cancer and its expression is frequently associated with poor prognosis. Our aim is to achieve gene knockdown by siRNA TMPRSS2-ERG and then to assess the biological consequences of this inhibition. First, we designed siRNAs against the two TMPRSS2-ERG fusion variants (III and IV), most frequently identified in pa...
هدف این پژوهش بررسی ارتباط عوامل انگیزشی-بهداشتی و عجین شدن با شغل کارکنان کمیتۀ ملی المپیک است که به روش توصیفی و شکل میدانی اجرا شده است. جامعۀ تحقیق شامل تمامی کارکنان کمیتۀ ملی المپیک بود و نمونۀ تحقیق به صورت تمام شمار تعیین شد. برای جمعآوری داده ها از دو پرسشنامۀ عوامل انگیزشی-بهداشتی دانت و همکاران و پرسشنامۀ عجین شدن با شغل لداهل و کجنر استفاده شد که پایایی آن ها بهترتیب 91/ 0و 79/0 م...
در محیط رقابتی دنیای امروز، کسب مزیت رقابتی یکی از چالش های اساسی مدیران است. منابع انسانی به عنوان یکی از مهم ترین منابع جهت ایجاد مزیت رقابتی شناخته می شود و کارکنانی که از منبع دانش بهره لازم را برده باشند دارای ارزش بیشتری در سازمان هستند. اهمیت بیشتر سازمان به دانشکاران، موجب به کارگیری راهبرد حفظ دانش توسط آنها می شود. محققان دریافته اند که آنچه به ایجاد مزیت رقابتی منجر می شود، دانش کارک...
BACKGROUND The associations of ERG overexpression with clinical behavior and molecular pathways of prostate cancer are incompletely known. We assessed the association of ERG expression with AR, PTEN, SPINK1, Ki-67, and EZH2 expression levels, deletion, and mutations of chromosomal region 3p14 and TP53, and clinicopathologic variables. METHODS The material consisted of 326 prostatectomies, 166...
AIM To investigate the existence of TMPRSS2:ERG fusion gene in circulating tumor cells (CTC) from prostate cancer patients and its potential in monitoring tumor metastasis. METHODS We analyzed the frequency of TMPRSS2:ERG and TMPRSS2:ETV1 transcripts in 27 prostate cancer biopsies from prostatectomies, and TMPRSS2:ERG transcripts in CTC isolated from 15 patients with advanced androgen indepen...
Recurrent gene fusions between the genes TMPRSS2 and ERG have been described in prostate cancer (PCa) and are found in 27% to 79% of radical prostatectomy. This fusion transcription results in ERG overexpression, which can be detected by immunohistochemistry (IHC) and provide a potential diagnostic marker for PCa. Three tissue microarrays (TMAs) containing samples from 98 patients with PCa and ...
ERG K+ channels have long been known to play a crucial role in shaping cardiac action potentials and, thus, appropriate heart rhythms. The functional role of ERG channels in the central nervous system, however, remains elusive. We demonstrated that ERG channels exist in subthalamic neurons and have similar gating characteristics to those in the heart. ERG channels contribute crucially not only ...
Purpose: We aimed to analyze whether ERG rearrangement in biopsies could be used to assess subsequent cancer diagnosis in high-grade prostatic intraepithelial neoplasia (HGPIN) and the risk of lymph node metastasis in early prostate cancer. Experimental Design: Samples from 523 patients (361with early prostate cancer and 162withHGPIN) were collected prospectively. On the basis of the cutoff val...
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