Proteasomes degrade most of the proteins inside eukaryotic cells, including transcription factors and regulators of cell cycle progression. Here we show that nanomolar concentrations of lactacystin, a specific irreversible inhibitor of the 20S proteasome, inhibit development of the exoerythrocytic and erythrocytic stages of the malaria parasite. Although lactacystin-treated Plasmodium berghei s...

After resective and reconstructive surgery in the gastrointestinal tract, oral feeding is traditionally avoided in order to minimize strain to the anastomoses and to reduce the inherent risks of the postoperatively impaired gastrointestinal motility. However, studies have given evidence that the small bowel recovers its ability to absorb nutrients almost immediately following surgery, even in t...

Bu araştırmada özel yetenekli öğrencilerin mizah anlayışları ile empatik eğilimleri arasındaki ilişkiyi ortaya koymak amaçlanmıştır. Ayrıca anlayışı ve eğilim düzeyleri çeşitli değişkenler açısından incelenmiştir. amaçlar doğrultusunda nicel araştırma yöntemlerinden nedensel karşılaştırma ilişkisel tarama modeli birlikte kullanılmıştır. Araştırmanın çalışma grubunu İstanbul ilinde bulunan Bilim...

Abstract By simply switching the electrical circuit installed on steel/steel contact, tribological behaviors of nanofluids (NFs) can be regulated in real time, thereby achieving desired performance friction reduction and wear resistance. Herein, solvent-free carbon spherical (C-NFs) were successfully prepared for intelligent lubrication regulation. C-NFs with excellent immediately reduce coeffi...