Cerebrospinal fluid (CSF) biomarkers T-Tau and Aβ(42) are linked with Alzheimer's disease (AD), yet little is known about the relationship between CSF biomarkers and structural brain alteration in healthy adults. In this study we examined the extent to which AD biomarkers measured in CSF predict brain microstructure indexed by diffusion tensor imaging (DTI) and volume indexed by T1-weighted ima...

The ground-state phases of mixed diamond chains with ($S, \tau^{(1)}, \tau^{(2)})=(1/2,1/2,1)$, where $S$ is the magnitude vertex spins, and $\tau^{(1)}$ $\tau^{(2)}$ are those apical investigated. spins connected each other by an exchange coupling $\lambda$. Other couplings set equal to unity. This model has infinite number local conservation laws. For large $\lambda$, ground state equivalent ...

BACKGROUND The measurement of hyperphosphorylated tau (p-tau) in CSF has been proposed as a biomarker candidate for the prediction of Alzheimer disease (AD) in patients with mild cognitive impairment (MCI). However, a standard quantitative criterion of p-tau has not been evaluated. OBJECTIVE To assess in a multicenter study the predictive accuracy of an a priori defined criterion of tau phosp...

Cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are currently being assessed with two different assays. Our objective was to study if there is a correlation between values obtained by both techniques, to compare their validity and search for conversion factor between values obtained for every protein. We compared the performances of two commonly used platforms, an enzyme-linked...

BACKGROUND Alzheimer's disease (AD), the most common cause of dementia in the elderly, has two pathological hallmarks: Aβ plaques and aggregation of hyperphosphorylated tau (p-tau). Aβ is a cleavage product of Amyloid Precursor Protein (APP). Presenilin 1 (PS1) and presenilin 2 (PS2) are the catalytic subunit of γ-secretase, which cleaves APP and mediates Aβ production. Genetic mutations in APP...

We present a family of differential models for the scaling exponents tau(p) which characterize the moments of the energy dissipation rate in turbulence. This scheme interpolates between the asymptotic values of the derivative tau'p of tau(p) versus p in the limits p-->+/-infinity and reproduces the negative-p part of the exponents spectrum tau(p) as well, in contrast with other recent conjectur...

BACKGROUND The CSF biomarkers tau and Abeta42 can identify patients with AD, even during the preclinical stages. However, previous studies on longitudinal changes of tau and Abeta42 in individual patients with AD and elderly controls report somewhat inconsistent results. METHODOLOGY/PRINCIPAL FINDINGS We investigated the levels of tau and Abeta42 at baseline and after 1 year in 100 patients w...

Differentiating dementia with Lewy bodies (DLB) from Alzheimer's Disease (AD) can be difficult because of the substantial overlap in clinical features. Since deficits in serotonergic and dopaminergic pathways seem more pronounced in DLB patients, we investigated whether cerebrospinal fluid (CSF) analysis of neurotransmitter metabolites, in addition to brain-specific proteins, may improve the di...

Previous studies indicate an important role for the cellular prion protein (PrP(C)) in the development of Alzheimer's disease (AD) pathology. In the present study, we analyzed the involvement of PrP(C) in different pathological mechanisms underlying AD: the processing of the amyloid-β protein precursor (AβPP) and its interaction with AβPP, tau, and different phosphorylated forms of the tau prot...