The cytotoxic effects of ecteinascidin-743(ET-743), a novel marine natural product, were evaluated and compared with that of clinically used anticancer agents methotrexate, doxorubicin, etoposide, and paclitaxel in eight human soft tissue sarcoma (STS) cell lines. HT-1080, a fibrosarcoma cell line, and HS-42, a malignant mesodermal cell line, were the most sensitive of the cell lines to methotr...

Janssen RPA, et al. JISAKOS 2017;2:308–317. doi:10.1136/jisakos-2016-000110. Copyright © 2017 ISAKOS AbstrAct Importance Controversy exists with respect to the best graft choice for anterior cruciate ligament reconstruction (ACLR) with accelerated, brace-free rehabilitation. Objective To investigate differences in clinical outcome between patellar tendon (PT) and hamstring tendon (HS) autograft...

For any integer s ≥ 0, we derive a combinatorial interpretation for the family of sequences generated by the recursion (parameterized by s) hs(n) = hs(n − s − hs(n − 1)) + hs(n − 2− s − hs(n − 3)), n > s + 3, with the initial conditions hs(1) = hs(2) = · · · = hs(s+2) = 1 and hs(s+3) = 2. We show how these sequences count the number of leaves of a certain infinite tree structure. Using this int...

BACKGROUND High-sensitivity troponin I (hs-TnI) and troponin T (hs-TnT) are moderately correlated and independently related to outcome in atrial fibrillation (AF). Rate controlling therapy has been shown to reduce hs-TnT, however the potential impact on hs-TnI levels, and whether this differs from the effects on hs-TnT, has not been investigated previously. METHODS Sixty patients with stable,...

BACKGROUND Nebulized hypertonic saline (HS) treatment is unavailable to large populations worldwide. OBJECTIVES To determine the bacterial contamination and electrolyte concentrations in homemade (HM-HS) vs. pharmacy made (PM-HS). METHODS We conducted three double-blind consecutive trials: 50 boiled-water homemade 3%-HS (B-HM-HS) bottles and 50 PM-HS. The bottles were cultured after 48 hour...

The Harmony Search (HS) method is an emerging meta-heuristic optimization algorithm. In this paper, we propose two modified HS methods to deal with the unimodal and multi-modal optimization problems. The first modified HS method is based on the fusion of the HS and Differential Evolution (DE) technique, namely, HS-DE. The DE is employed here to optimize the members of the HS memory. The second ...