background: (PCOS) is among the most common types of gynecological hormonal abnormalities and metabolic problems that have an impact females throughout adolescence, with a prevalence 6-10%.Hyperandrogenism, unreliable menstrual periods, polycystic ovaries are hallmarks PCOS. The (HPG) axis controlled by kisspeptins, peptides made KISS1 gene.Objectives: This investigation's objective about used ...

Department of Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran Department of Ophthalmology, Student Research Committiee, Shiraz University of Medical Sciences, Shiraz, Iran Research Center for Non-Communicable Diseases, Jahrom University of Medical Sciences,...

Contents 1. Introduction: Interface between nutrition, reproduction and animal production 2. Basic aspects on intermediary metabolism: Hormonal control of energy homeostasis 3. Basic aspects of reproduction: Neuroendocrine regulation 4. Integration of nutrition and reproduction: Neuroendocrine mechanisms 5. Direct roles of nutrition in modulating reproductive function 6. The Kiss1 system: Novel...

Objective(s): Several pathological conditions are associated with hyper-production of testosterone; however, its impacts are not well understood. Hence, we evaluated the effects of supraphysiological levels of testosterone on gonadotropin-releasing hormone (GnRH) system in the hypothalamus of male rats. Also, we assessed the expression of two excitatory (kisspeptin and...

BACKGROUND The hypothalamus plays a key role in mediating the effects of estrogen on many physiological functions, including reproduction, metabolism, and thermoregulation. We have previously observed marked estrogen-dependent gene expression changes within the hypothalamus of rhesus macaques during aging, especially in the KNDy neurons of the arcuate-median eminence (ARC-ME) that produce kissp...