mers or ADDLs appear to accumulate in the AD brain. These soluble aggregates have been shown to be potent neurotoxins that can acutely disrupt neuronal func-In this issue of Neuron, a study by Billings et al. tion in vivo. The limited immunohistochemical studies points to intracellular A␤ as a possible cause of neu-using antibodies that recognize these oligomers or ronal dysfunction. In a mouse...

The increased levels of automation in current generation aircraft have lead to a new set of human factors related concerns. This set of problems is suspect in a large number of incidents. These include a crash caused by autopilot disconnect confusion in an A300 at Nagoya, incorrect mode selection in an A320 at Strausbourg, overspeed problems with the B757 and several others. Billings has synops...

MASSACHUSETTS ANTI-TUBERCULOSIS LEAGUE Fourth Annual Meeting, Boston, April 11, 1918. Introductory Remarks by the President. By Vincent Y. Bowditch, M.D., Boston 847 Adequate Community Organization for Health Educational Woks. By Mary A, Abel, Framingham, Mass. 850 Relative Values in Anti-Tuberculosis Work. By Professor C. M. Billiard, Boston 853 Annual Report of the Massachusetts Anti-Tubercul...