Introduction : The present study is aimed at investigation of the mechanism action a new 3-substituted thietane-1,1-dioxide derivative (N-199/1) exhibiting antidepressant properties, in several tests neuropharmacological interaction. Materials and methods To N-199/1, its effect on 5-hydroxytryptophan (5-HTP)-induced head-twitch response (50 mg/kg 300 mg/kg), haloperidol-induced catalepsy (1 are...

NK cells have usually been defined as of the innate immune system, although they are also involved in adaptative responses. These belong to lymphocyte (ILC) family. They remove unwanted cells, tumoral and pathogens. essential for viral infection clearance tolerogenic responses depending on dynamic balance repertoire activating inhibitory receptors. plasticity is crucial tissue function vigilant...

the present study investigated the effects of microinjections of acetylcholine (a cholinergic agonist), physostigmine (a cholinesterase inhibitor), atropine (an antagonist of muscarinic cholinergic receptors) and hexamethonium (an antagonist of nicotinic cholinergic receptors) into the parafascicular nucleus of thalamus on the acute corneal nociception in rats. acute corneal nociception was ind...

Cannabinoids reduce tremor associated with motor disorders induced by injuries and neurodegenerative disease. Here we show that this effect is mediated cannabinoid receptors on astrocytes in the ventral horn of spinal cord, where alternating limb movements are initiated. We first demonstrate reduced a mouse model essential after intrathecal injection analog WIN55,212-2. investigate underlying m...