The parts of the RNA genome of infectious bronchitis virus (IBV) required for replication and packaging of the RNA were investigated using deletion mutagenesis of a defective RNA (D-RNA) CD-61 (6.1 kb) containing a chloramphenicol acetyltransferase reporter gene. A D-RNA with the first 544, but not as few as 338, nucleotides (nt) of the 5' terminus was replicated; the 5' untranslated region (UT...

Rhagoletis fruit flies are important both as major agricultural pests and as model organisms for the study of adaptation to new host plants and host race formation. Response to fruit odor plays a critical role in such adaptation. To better understand olfaction in Rhagoletis, an expressed sequence tag (EST) study was carried out on the antennae and maxillary palps of Rhagoletis suavis (Loew) (Di...

SCY-635: A Novel Non-Immunosuppressive Analog of Cyclosporin A that Exhibits 1 Potent Inhibition of Hepatitis C Virus RNA Replication in vitro 2 3 4 Running Title: 5 SCY-635 Inhibits HCV RNA Replication in vitro 6 7 8 Sam Hopkins, 1* Bernard Scorneaux, 1 Zhuhui Huang, 3 Michael G. Murray, 3 Stephen 9 Wring, 1 Craig Smitley, 1 Richard Harris, 1 Frank Erdmann, 2 Gunter Fisher, 2 Yves Ribeill 1 10...

Some details of 544 episodes of infective endocarditis occurring in 541 patients during 1981 and 1982 are reported. The mean age of patients was 51.6 years and there was a greater proportion of males (2:1). Of the 544 episodes 347 (63%) were due to streptococci, 19% to staphylococci, and 14% to bowel organisms. A wide variety of other organisms were responsible for a few cases, and 10% were cul...

By emulating some of the 'early' vision processes believed to occur in the visual cortex of mammals, dramatic savings can be made in the computational efforts usually associated with image processing. This paper describes the design and implementation of a low-cost visual tracking system that uses no special signal processing, vector processing nor floatingpoint hardware. Its effectiveness reli...

BACKGROUND The prevalence of ischemia on nuclear myocardial perfusion imaging (MPI) has been decreasing. Recent research has questioned the benefit of invasive revascularization for patients with moderate to severe ischemia. We hypothesized that patients with moderate to severe ischemia could routinely undergo successful revascularization. METHODS We analyzed data from 544 patients who underw...

BACKGROUND Recurrent ovarian clear cell carcinoma (CCC) rarely responds to cytotoxic agents. Itraconazole is a potent inhibitor of the P-glycoprotein efflux pump, angiogenesis, and the Hedgehog pathway. We evaluated the efficacy of chemotherapy with itraconazole for CCC. PATIENTS AND METHODS Medical charts of patients with CCC who had received chemotherapy with itraconazole were retrospective...