whenever ‖~v‖V < δ. In this case the bounded linear operator dF~v0 is called the (Frechet) derivative of F at ~v0. Prove that if ‖ • ‖V is a norm on V which is equivalent to ‖ • ‖V , then F is differentiable at ~v9 with respect to ‖ • ‖V if and only if it is differentiable at ~v0 with respect to ‖ • ‖V , and in this case the derivatives are equal. Similarly, if ‖ • ‖W is a norm on W which is eq...

3. The Implicit Function Theorem and its special case, the Inverse Function Theorem. Relation to the Contraction Mapping Fixed Point Theorem. Computation of several iterates of the approximating sequence to the implicit function. Continuity and differentiability of the implicit function. Application to differentiable variation of the fixed point in the Contraction Mapping Fixed Point Theorem. 4...

Dysregulation of microRNAs has been confirmed to serve an important role in cancer development and progression. However, the role of microRNA (miR)-544 in colorectal cancer progression remains unknown. In the present study, it was observed that the expression level of miR-544 was increased in breast cancer cell lines and tissues using the quantitative polymerase chain reaction. Overexpression o...

PURPOSE CMC-544 is a CD22-targeted immunoconjugate of calicheamicin and exerts a potent cytotoxic effect against CD22+ B-cell lymphoma. This study evaluated antitumor efficacy of CMC-544 against systemically disseminated B-cell lymphoma. EXPERIMENTAL DESIGN Scid mice received i.v. injections of CD22+ Ramos B-cell lymphoma cells for their systemic dissemination. CMC-544, G5/44, CD33-targeted C...

PURPOSE CMC-544 is a CD22-targeted cytotoxic immunoconjugate, currently being evaluated in B-cell non-Hodgkin's lymphoma (B-NHL) patients. Rituximab is a CD20-targeted antibody commonly used in B-NHL therapy. Here, we describe antitumor efficacy of a combination of CMC-544 and rituximab against B-cell lymphoma (BCL) in preclinical models. EXPERIMENTAL DESIGN BCLs were cultured in vitro with C...

conclusions: the results showed that silver nanoparticles have an antimicrobial effect against intramacrophage b. abortus 544. results: the well diffusion agar study showed that silver nanoparticles have an antimicrobial effect on b. abortus 544. the mic and mbc of silver nanoparticles against b. abortus 544 were; 6 ppm and 8 ppm, respectively. the silver nanoparticles showed antibacterial effe...

BACKGROUND Brucellosis is an infectious disease that is caused by Brucella spp. As Brucella spp. are intramacrophage pathogens, the treatment of this infection is very difficult. On the other hand, due to the side effects of the brucellosis treatment regime, it is necessary to find new antimicrobial agents against it. OBJECTIVES The aim of this study was to investigate the antimicrobial effec...

Antibody-targeted chemotherapy with gemtuzumab ozogamicin (CMA-676, a CD33-targeted immunoconjugate of N-acetyl-gamma-calicheamicin dimethyl hydrazide [CalichDMH], a potent DNA-binding cytotoxic antitumor antibiotic) is a clinically validated therapeutic option for patients with acute myeloid leukemia (AML). Here, we describe the preclinical profile of another immunoconjugate of CalichDMH, CMC-...

OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 543 STRUCTURE OF GENERAL FACTORIAL DESIGNS . . . . . . . . . . . 543 SUITABLE CONFOUNDING RULES . . . . . . . . . . . . . . . . . . . . . 544 Design Factors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 544 Block Factors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 545 Gener...

is available from Contraception through Science Direct here. Corresponding author: David Hubacher Family Health International PO Box 13950 Research Triangle Park, NC 27709 USA Phone: 919-544-7040 x223 Fax: 919-544-7261 E-mail address: [email protected]