conclusions this study showed that compared to standard drug treatment, treatment with hydrogel containing peptide had substantial antibacterial effects on s. aureus wound infections in mice. results the highest and lowest numbers of wounds were observed on day 2 in the negative and positive control groups, respectively. during the 8-day period, the positive control and hydrogel containing pept...

The effects of the composition and rheology of the fermentation medium on the antibiotic production by Streptomyces hygroscopicus CH-7 were studied. To increase the yields of hexaene H-85 and elaiophylin, the basic fermentation medium was reformulated using different carbon (glucose, lactose, ribose, fructose and trehalose) and nitrogen (isatin-Schiff bases) sources. The maximum yields of hexae...

I-Chan Huang UFCOM [email protected] (352) 265-2514 Wendy Leisenring FHCRC [email protected] (206) 667-4374 Gwendolyn Quinn MCC [email protected] (813) 745-1359 Elizabeth Shenkman UFCOM [email protected] (352) 265-2547 Kelly Kenzik UFCOM [email protected] (352) 265-2572 Mandy Li BC [email protected] (617) 552-4534 Tara Brinkman SJCRH [email protected] (901) 595-5683 Christopher Rec...

Let q > 1 and E be a real q-uniformly smooth Banach space, K be a nonempty closed convex subset of E and T : K → K be a Lipschitz continuous mapping. Let {un} and {vn} be bounded sequences in K and {αn} and {βn} be real sequences in [0, 1] satisfying some restrictions. Let {xn} be the sequence generated from an arbitrary x1 ∈ K by the Ishikawa iteration process with errors: yn = (1− βn)xn + βnT...

OBJECTIVES The Newcastle 85+ Study aims to systematically study the clinical, biological, and psychosocial attributes of an unselected cohort of 85 year olds and to examine subsequent health trajectories as the cohort ages; health at baseline is reported. DESIGN Cross sectional analysis of baseline data from a cohort study. SETTING Newcastle upon Tyne and North Tyneside primary care trusts,...

Ion mobility spectrometry-mass spectrometry (IMS-MS) techniques are used to study the general effects of phosphorylation on peptide structure. Cross sections for a library of 66 singly phosphorylated peptide ions from 33 pairs of positional isomers, and unmodified analogues were measured. Intrinsic size parameters (ISPs) derived from these measurements yield calculated collision cross sections ...

Naturally processed peptides were acid extracted from immunoaffinity-purified HLA-DR2, DR3, DR4, DR7, and DR8. Using the complementary techniques of mass spectrometry and Edman microsequencing, > 200 unique peptide masses were identified from each allele, ranging from 1,200 to 4,000 daltons (10-34 residues in length), and a total of 201 peptide sequences were obtained. These peptides were deriv...

A plasmid-linked antimicrobial peptide, named coagulin, produced by Bacillus coagulans I(4) has recently been reported (B. Hyronimus, C. Le Marrec and M. C. Urdaci, J. Appl. Microbiol. 85:42-50, 1998). In the present study, the complete, unambiguous primary amino acid sequence of the peptide was obtained by a combination of both N-terminal sequencing of purified peptide and the complete sequenc...

Extracellular vesicles (EVs) secreted by prostate cancer (PCa) cells contain specific biomarkers and can be isolated from urine. Collection of urine is not invasive, and therefore urinary EVs represent a liquid biopsy for diagnostic and prognostic testing for PCa. In this study, we optimised urinary EV isolation using a method based on heat shock proteins and compared it to gold-standard ultrac...