gene, however, progression-free survival was nearly doubled in the cetuximab/BSC group at 3.8 months, compared with 1.8 months in the BSC-alone group (P < 0.0001). For the primary endpoint of overall survival, again among patients with mutated K-ras genes, findings were similar: 4.5 months for cetuximab plus BSC and 4.6 months for BSC alone (P = 0.89). For wild-type K-ras, there was a significa...

We consider Bott-Samelson varieties BSc(s) for a semisimple compact Lie group C corresponding to sequences of (not necessarily simple) reflections s. Let n be the length s, K maximal torus in and W Weyl C. For any set R not overlapping integer pairs (i,j) such that 1?i?j?n function v:R?W, we subspace BSc(s,v)?BSc(s) solutions equations C/K requiring K-orbit product coordinates counted from i j ...

Despite the fact that since its launch by Kaplan and Norton (1992) professional and academic discourse on the Balanced Scorecard (BSC) is intense, it is not clear to what extent organizational changes are induced by and associated with this discourse. An intensive BSC-discourse may not be equated with a large amount of actual changes within organizations. This paper’s aim is to contribute to un...

The objective of this article is to develop a Balanced Scorecard (BSC) for Sustainable Supply Chain Management (SSCM). The BSC provides a framework for simulation experiments which serve to evaluate benefits of sustainability investments for the partners within a recycling supply chain. A system dynamics approach was employed to perform the simulation experiments. First, the simulations help to...

The intestinal nematode Baylisascaris schroederi is an important cause of death for wild and captive giant pandas. Inorganic pyrophosphatases (PPases) are critical for development and molting in nematode parasites and represent potential targets for vaccination. Here, a new PPase homologue, Bsc-PYP-1, from B. schroederi was identified and characterized, and its potential as a vaccine candidate ...

 T. O. White, FRCSEd(Tr&Orth), MD, FFTEd, Consultant Orthopaedic Trauma Surgeon  S. P. Mackenzie, MBChB, BSc MedSci (Hons), MRCS, Specialty Registrar  T. H. Carter, BSc(Hons), MBChB, MRCS(Ed), Specialty Registrar  O. R. Prescott, BSC BMBS PGCert, Foundation Doctor  A. D. Duckworth, BSc(Hons), MBChB, MSc, FRCSEd(Tr&Orth), PhD, Specialty Registrar  J. F. Keating, MPhil, FRCSEd(Tr&Orth), Con...

We introduce a community detection algorithm (Fluid Communities) based on the idea of fluids interacting in an environment, expanding and contracting as a result of that interaction. Fluid Communities is based on the propagation methodology, which represents the state-of-the-art in terms of computational cost and scalability. While being highly efficient, Fluid Communities is able to find commu...

BACKGROUND To compare volume reserve capacity (VRC) and development of intra-abdominal hypertension after different in vitro temporary abdominal closure (TAC) techniques. METHODS A model of the abdomen was designed. The abdominal wall was simulated with polychloroprene, a synthetic rubber compound. A lentil-shaped defect of 150 cm(2) was cut into the anterior aspect of the abdominal wall. TAC...

PURPOSE The prognosis of platinum-based chemotherapy-resistant metastatic urothelial cancer of the bladder remains poor. Personalized selection of the right peptides for each patient could be a novel approach for a cancer vaccine to boost anticancer immunity. EXPERIMENTAL DESIGN In this randomized, open-label, phase II study, patients ages ≥18 years with progressive bladder cancer after first...

A bumetanide-sensitive Na-K-2Cl cotransporter, BSC-1, is believed to mediate the apical component of transcellular NaCl absorption in the thick ascending limb (TAL) of Henle's loop. To study its ultrastructural localization in kidney, we used an affinity-purified, peptide-derived polyclonal antibody against rat BSC-1. Immunoblots from rat kidney cortex and outer medulla revealed a solitary 161-...