The acute and sub-acute toxicity of safranal were studied in rat and mice within 2 and 21 days after exposure, respectively. For subacute toxicity, changes in weight as well as biochemical, hematological and pathological parameters were studied. The intraperitoneal LD50 values of safranal were 1.48 mL/kg in male mice, 1.88 mL/kg in female mice and 1.50 mL/kg in male rats. Oral LD50 values were ...

Corresponding author: Assist. Boris Ž. MILIJAŠEVIĆ, MD, PhD Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, 3 Hajduk Veljkova Str., 21000 Novi Sad, Serbia E-mail: [email protected] © Th e Se rb ia n M ed ic al S oc ie ty 2 01 4 The Influence of Detoxification Agents on the Intensity of Side Effects Caused by Medium-high Doses of Me...

Objective: Pinus eldarica (P. eldarica) is one of the most common pines in Iran which has various bioactive constituents and different uses in traditional medicine. Since there is no documented evidence for P. eldarica safety, the acute and sub-acute oral toxicities of hydroalcoholic extract of P. eldarica bark were investigated in male and female Wistar rats in this study. Materials and Method...

Background: Well-controlled clinical studies in the developed world have shown that probiotics can shorten the duration of acute non-bacterial diarrhea. We aimed to evaluate the efficacy of a probiotic consisting of a mixture of Lactobacillus acidophilus and Bifidobacterium bifidum in the treatment of young children with acute diarrhea in Mashad, Iran Methods: Sixty-two hospital inpatients aged...

.............................................................................................................................. 1 POPULÄRVETENSKAPLIG SAMMANFATTNING............................................................. 3 LIST OF PAPERS...................................................................................................................... 5 ABBREVIATIONS.........................

Metabonomics and its many pseudonyms (metabolomics, metabolic profiling, etc.) have exploded onto the scientific scene in the past 2 to 3 years. Nowhere has the impact been more profound than within the toxicology community. Within this community there exists a great deal of uncertainty about whether metabonomics is something to count on or just the most recent technological flash in the pan. M...

Recent advances in analytical techniques have enabled the detection of drugs and drug metabolites in alternative biological specimens for the purposes of workplace testing. A wide variety of specimens are available, each providing valuable information concerning prior or current drug use. The present focus is on oral fluid (saliva), hair, and sweat. An extensive evaluation by the Division of Wo...