نتایج جستجو برای: adrenoreceptors
تعداد نتایج: 330 فیلتر نتایج به سال:
UNLABELLED (S)-(11)C-CGP12388 ((11)C-CGP12388) was recently developed as an in vivo PET tracer for the evaluation of cardiac beta-adrenergic receptors. The purpose of this study was to evaluate the myocardial kinetics of (11)C-CGP12388 using the perfused rat heart model. METHODS Normal rat hearts were cannulated for retrograde perfusion according to the Langendorff method. Studies were perfor...
(S)-11C-CGP12388 (11C-CGP12388) was recently developed as an in vivo PET tracer for the evaluation of cardiac -adrenergic receptors. The purpose of this study was to evaluate the myocardial kinetics of 11C-CGP12388 using the perfused rat heart model. Methods: Normal rat hearts were cannulated for retrograde perfusion according to the Langendorff method. Studies were performed using constant cor...
OBJECTIVE We assessed whether alpha1-adrenoreceptor (alpha1-AR) stimulation contributes to activation of myocardial NADPH oxidase in a rat model of cocaine-induced cardiac dysfunction. METHODS AND RESULTS After 7 days of cocaine injection (2 x 7.5 mg/kg/day, i.p., Coc), NADPH activity assessed by chemiluminescence increases as well as phosphorylation of p47phox, one of the cytosolic component...
Cultured mesenchymal stromal cells (MSCs) from different sources represent a heterogeneous population of proliferating non-differentiated cells that contains multipotent stem cells capable of originating a variety of mesenchymal cell lineages. Despite tremendous progress in MSC biology spurred by their therapeutic potential, current knowledge on receptor and signaling systems of MSCs is mediocr...
Alterations in cardiac function were observed in antidepressants treated patients and published in several clinical reports. These detected changes could be either a consequence of the treatment or of depression itself, which has already been proved to be a risk factor in heart diseases. In order to determine a possible influence of chronic treatment with norepinephrinergic reuptake inhibitor, ...
Stress has an emerging role in cancer and targeting stress-related β-adrenergic receptors (AR) has been proposed as a potential therapeutic approach in melanoma. Here we report that β3-AR expression correlates with melanoma aggressiveness. In addition, we highlight that β3-AR expression is not only restricted to cancer cells, but it is also expressed in vivo in stromal, inflammatory and vascula...
Molds secrete over 400 different mycotoxins, all of which are toxic to all humans. Everyone in a mycotoxin contaminated environment will have fatigue and other systemic symptoms, but may write them off to other causes. Fatigue from mycotoxin exposure indicates multisystem systemic toxicity. Even individuals with no exaggerated immune response to fungal/mold/yeast antigens, and therefore showing...
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