UNLABELLED Agonism of alpha-adrenoreceptors has a powerful anesthetic result mediated, in part, by effects on the spinal cord. Alpha-adrenoreceptor agonists (e.g., dexmedetomidine) can decrease the minimum alveolar anesthetic concentration (MAC) of inhaled anesthetics (e.g., halothane) to zero, with an apparently additive interaction between halothane and dexmedetomidine. We tested whether the ...

Abstract. Topicality. Endothelial dysfunction is a key link in the pathogenesis, formation and progression of clinical manifestations significant number cardiovascular system diseases. Some pathogenetic links structures associated with morphofunctional disorders cardiac endothelial cells under stress conditions its combination hypercholesterolemia need further examination.
 The aim study w...

We have previously shown differences in the intracellular targeting of alpha2a (alpha(2A))- and alpha2c (alpha(2C))-adrenoreceptors expressed in the same cell line (von Zastrow, M., Link, R., Daunt, D. , Barsh, G., and Kobilka, B. (1993) J. Biol. Chem. 268, 763-766; Daunt, D. A., Hurt, C., Hein, L., Kallio, J., Feng, F., and Kobilka, B. K. (1997) Mol. Pharmacol. 51, 711-720). alpha(2A)-Adrenore...

Post acne erythema (PAE) is a common sequalae in many patients. This due to wound healing-related dilatory changes microvascular structures such as the microcapillary plexus very superficial dermis which are not detectable by naked eye visible telangiectasia but general redness. Lesions appear telangiectatic and erythematous macules result from skin inflammation. Oxymetazoline synthetic, direct...

Usage of cyclosporine A (CsA) after kidney transplantation may be associated with development of nephrotoxicity and vasculopathy, but the mechanisms by which CsA causes vascular dysfunction are still under scrutiny. We established a transplantation model and investigated the effect of CsA on vascular contractility with the aid of a pressurized myograph in comparison with control and unilaterall...

Changes in platelet a2 adrenoreceptors and their relation to plasma catecholamine concentrations were studied in 11 patients with acute transmural myocardial infarction. A radiolabelled a2 adrenoreceptor antagonist, [3H]-yohimbine, was used to assay x2 adrenoreceptors on platelet membranes, and plasma catecholamine concentrations were measured by high performance liquid chromatography. The numb...

Cardiovascular medicine is a leading area of pharmacogenomics (PGx). A number of PGx studies have linked genetic polymorphisms to patients’ response to the drugs in the pharmacotherapy against cardiovascular diseases. Among them, PGx of adrenoceptors is one of the most important fields, because adrenergic networks play important roles in cardiovascular systems. The excess of adrenergic stimuli ...

Snjezana Milicevic Urology Clinic, Clinical Center Banjaluka, Bosnia and Herzegovina by its thickness and volume, in patients with BPh, in quantitative estimation of hypertrophy degree. Enlarged prostate causes two types of obstruction: a dynamic and mechanical. Functional obstruction (dynamic factor) stems from contractile smooth muscles of the prostate and the urinary bladder neck, which are ...

The study was made with the help of a chemitrode placed in various areas of the hypothalamus by the stereotaxic technique, for electrical and chemical stimulation (noradrenaline or isoprenaline) before and after microinjection of respective blockers (phenoxybenzamine or practalol). The results indicated the presence of both alpha and beta-adrenoreceptors in the anterior and dorsomedial hypothal...

We have recently shown that ventricular unloading with an implantable left ventricular assist device (LVAD) leads to improved calcium handling and membrane integrity and redistribution of alpha adrenoreceptors (AARs) and betaadrenoreceptors (BARs). Here, we used fluorescence deconvolution microscopy to examine the effect of LVAD type (pulsatile vs non-pulsatile) on upregulation and redistributi...