background non-alcoholic fatty liver disease (nafld) is a common liver disease in the western population and expanding disease in the world. pathological changes in fatty liver are like alcohol liver damage, which can lead to end-stage liver disease. the prevalence of nafld in obese or overweight people is higher than general population, and it seems that people with high body mass index (bmi) ...

conclusions according to the results of this meta-analysis, there was a high risk of nafld in women with pcos. we suggest evaluating patients with pcos regarding nafld. results we finally included seven eligible studies. according to chi-squared test, there was a significant heterogeneity (73.6%) between studies (p = 0.001). nafld prevalence was significantly higher in patients with pcos compar...

conclusions in the chinese han population that we studied, nafld patients who carry the tnf-α-238 ga polymorphism have an increased risk of developing cad. mechanisms underlying this potentially important association require further investigation. background cardiovascular events account for the main cause of death in patients with non-alcoholic fatty liver disease (nafld), and are largely infl...

background: increasing evidence suggests an association between ele­vated serum aminotransferase levels and metabolic disorders (metabolic syndrome, hyperlipemia and diabetes mellitus). however, the significance of relatively low levels of aminotransferases in relation to metabolic disorders has not been fully investigated in the general population. we inves­tigated the association between seru...

NAFLD (non-alcoholic fatty liver disease) represents a spectrum of fatty liver diseases associated with an increased risk of Type 2 diabetes and cardiovascular disease. The spectrum of fatty liver diseases comprises simple steatosis, steatosis with inflammation [i.e. NASH (non-alcoholic steatohepatitis)], fatty liver disease with inflammation and fibrosis (severe NASH) and cirrhosis. The molecu...

AIMS The aim of this review was to focus on the knowledge of the role of lipin-1 in the pathogenesis of alcoholic fatty liver. METHODS Systematic review of animal clinical and cell level studies related to the function of lipin-1 on alcoholic fatty liver, alcoholic hepatitis and alcoholic liver cirrhosis disease. RESULT Ethanol could increase the expression of lipin-1 through the AMPK-SREBP...

BACKGROUND Portal vein embolization is essential for patients with biliary cancer who undergo extended hepatectomy to induce hypertrophy of the future remnant liver. Over 830 patients have undergone the portal vein embolization at our institution since 1990. Non-alcoholic fatty liver disease is an entity of hepatic disease characterized by fat deposition in hepatocytes. It has a higher prevalen...

Alcoholic liver disease (ALD) is a global liver disease which characterized by liver inflammation, fatty liver, alcoholic hepatitis, or liver cirrhosis. Alcohol abuse is one of the main reasons for liver disease. Alcoholic fatty liver (AFL) disease is the early stage of ALD and associated with the excessive lipids accumulation in hepatocytes as well as oxidative stress. MicroRNA-203 (miR-203) i...