PURPOSE In vitro disintegration and dissolution are routine methods used to assess the performance and quality of oral dosage forms. The purpose of the current work was to determine the potential for interaction between capsule shell material and a green tea extract and the impact it can have on the release. METHODS A green tea extract was formulated into simple powder-in-capsule formulations...

The main components for tablet formulations are the fillers, binders, crushers, thinners and lubricants. Among these components, binders play a key role on powder cohesion properties during formation of granules. In this study, turmeric extract tablets were formulated using 15 g extract, 35 aerosil, 12.8 lactose, 1% magnesium stearate, 200 ml aquadest gelatin as binder. To evaluate effect formu...

In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are bioactive and biodegradable grafting bioceramics in the form of a powder and a liquid. After mixing, both phases form pastes, which set and harden forming either a non-stoichiometric calcium deficient hydroxyapatite or brushite. Since both of them are remarkably biocompartible, bioresorbable and osteoc...

SUMMARY Roller compacted hydrophilic polymer combinations were used to formulate verapamil hydrochloride (HCl) extended release hydrophilic matrix tablets. The effect of roller compaction (RC) parameters on the properties of blended polymers, tablets and drug release were investigated. RC granulation improved the powder properties without affecting the pharmacotechnical properties or the drug r...

The objectives of present investigations were to optimize concentration of oil, surfactant and cosurfactant by pseudoternary phase diagrams and to develop a stable formulation of self emulsifying drug delivery system (SEDDS) in order to enhance the dissolution rate of poorly soluble Irbesartan (IBS) by SEDDS. Pseudoternary phase diagrams were constructed to identify the self emulsifying region....

This Part I paper describes the qualification of a new high performance hypromellose (hydroxypropyl methylcellulose, HPMC) capsule shell which contains no gelling agent and is dissolution friendly. The development history and the test results for a series of quality attributes including scanning electron microscopy, hygroscopicity, machineability, weight variation, powder leakage, mechanical st...

In recent years natural polymers have been widely used because of their effectiveness and availability over synthetic polymers. In this present investigation matrix tablets of Metformin hydrochloride were formulated using Water hyacinth powder and its rate retardant activity was studied. Tablets were prepared using wet granulation method with 8% starch as granulating agent and 5, 10, 15, 20, 25...