Pemphigus foliaceus (PF) is an autoimmune disease characterized by blistering of the skin. Infections caused by members of the herpesviridae family have been suggested as a possible triggering factor for pemphigus vulgaris (PV), but not for PF. The present study aimed to investigate the presence of Human herpesvirus (types 1, 2, 3) in corticosteroid refractory skin lesions from a patient with P...

An electrochemiluminescence-polymerase chain reaction (ECL-PCR) method for point mutation detection has been developed. The target is amplified using a tris (bipyridine) ruthenium (TBR)-labeled forward and a biotinylated reverse primer. The amplification products are digested with specific restriction enzyme, then captured onto streptavidin-coated paramagnetic beads, and detected by measuring t...

meduiiary thyroid carcinoma (mtc) occurs both sporadically and in the autosomal dominantly inherited multiple endocrine neoplasia (men) type 2 syndromes. the distinction between true sporadic mtc and a new mutation familial case is important for future clinical management of both the patient and family. the susceptibility gene for hereditary mtc is the ret proto-oncogene. dna analysis for germl...

glucose-6-phosphate dehydrogenase (g6pd) is a cytosolic enzyme which its main function is to produce nadph in the red blood cells by controlling the step from glucose-6-phosphate to 6-phospho gluconate in the pentose phosphate pathway. g6pd deficiency is the most common x-chromosome linked hereditary enzymopathy in the world, that result in reduced enzyme activity and more than 125 different mu...

objective(s) p53 is an important tumor suppressor, which is mutated in later stages of many cancers and leads to resistance to chemotherapy. the aim of this study was to reveal mutations of tp53 in colorectal cancer in kerman province. materials and methods a total of forty-three colon cancer specimens as paraffin block or fresh tissues, which passed stage iiia, were selected. three exons 5, 7 ...

BACKGROUND Exploring the rate of naturally occurring NS3 protease mutants in HCV infected population is influential in the future therapeutic approaches. OBJECTIVES This study explored naturally occurring resistant mutations to protease inhibitors in a pilot study. PATIENTS AND METHODS We analyzed NS3 gene sequences in 7 HCV infected patients, referred to the central liver center, south of ...

Consider a two-type Moran population of size $N$ with selection and mutation, where the selective advantage fit individuals is amplified at extreme environmental conditions. Assume mutation are weak respect to $N$, conditions rarely occur. We show that, as $N\to\infty$, type frequency process time speed up by converges solution Wright-Fisher-type SDE jump term modeling effect environment. use a...

background: trichomoniasis is a worldwide protozoan parasitic disease and metronidazole is a choice drug for its treatment. because of disease importance in public health and its controversial ideas about the prevalence of drug resistance, this study was carried out. methods: fifty-two suspected vaginal samples were collected from 2006 to 2007 in gynecology maryam hospital, tehran, iran. all is...

Tuberous sclerosis complex is a rare autosomal dominant genetic disorder that affects multiple organ systems, primarily affecting the central nervous system. It develops with pathogenic mutation in tumour suppressor genes i.e. Sclerosis Complex 1 or 2 which codes for protein hamartin and tuberin leading to unopposed hyperactivation of mammalian target rapamycin signalling pathway. presents tria...