A series of 2-methylthio-1,4-dihydropyrimidine derivatives (II) were synthesized in good yields by alkylation of 1,2,3,4-tetrahydropyrimidines (I) with methyl iodide in the presence of pyridine. Their structures were confirmed by elemental analysis, IR and 1H NMR spectra. The compounds were tested for analgesic activity by acetic acid induced writhing method. Compounds IIh, IIe, IIk and IIl sho...

The roots of Flemingia strobilifera were extracted in absolute methanol to determine their analgesic activity. The analgesic activity was assessed on intact mice by tail flick latency in tail immersion method. Acetylsalicylic acid in the dose of 300 mg/kg is used as standard drug. Plant extracts were given in the doses of 300, 500 and 1000 mg/kg. Control group received 0.9% NaCl (saline) soluti...

In traditional medicine,some of the plants have been used as analgesic effect of teucrium polium (TP) used traditionally to relieve headache,rheumatic arteritis and pain during pregnancy.for this purpost the perculated and suxheleted extracts of TP, with differnt doses,were injected intraperitonealy to the mice and the analgesic effect was determined by Tail Flick test(TF) and formalin test(FT)...

Rodent evidence has confirmed the analgesic effect of tricyclic antidepressants in the treatment of chronic pain, which amitriptyline is rigorously verified. The analgesic effect of amitriptyline, whose mechanisms are complex and unclear, is different from its antidepressant effect. This article reviewed the mechanisms behind amitriptyline’s analgesic properties to further understanding of this...

Key Points  Many novel analgesic formulations developed for human use are not practical or effective in veterinary patients  Available or pipeline novel analgesic formulations for veterinary patients are targeted towards extended delivery or ease of administration  Some novel analgesic formulations revolve around “old” analgesics (e.g. opioids) in a novel delivery matrix; however, while the ...

Uses Actions Fentanyl is a potent narcotic analgesic with a rapid onset and short duration of action. The principal actions of therapeutic value are analgesia and sedation. At a dose of 100 micrograms (2 mL), the analgesic activity of fentanyl is approximately equivalent to 10 mg of morphine or 75 mg of pethidine. Fentanyl differs from morphine by its short duration of analgesic activity, lack ...

a series of 2-methylthio-1,4-dihydropyrimidine derivatives (ii) were synthesized in good yields by alkylation of 1,2,3,4-tetrahydropyrimidines (i) with methyl iodide in the presence of pyridine. their structures were confirmed by elemental analysis, ir and 1h nmr spectra. the compounds were tested for analgesic activity by acetic acid induced writhing method. compounds iih, iie, iik and iil sho...

the development of combination therapy is a coherent approach in severe pain treatment. the present study investigated the antinociceptive effect of pregabalin alone and in combination with tramadol in acute pain modeling. therefore, three groups of male mice received either pregabalin (1 to 400 mg/kg), tramadol (10 to 80 mg/kg) or their combination intraperitoneally. then latency time, maximum...

nimodipine, an l-type calcium channel blocker, can induce analgesia. however, it is not clear that this analgesic effect is at the level of spinal or supraspinal pain pathway. in addition, it has been reported that the analgesic effect of nifedipine, another l-type calcium channel blocker is related to the hpa axis, but there is no report indicating the role of this axis in the analgesic effect...

  Bibliographical studies have been done on plants that are used as analgesics in traditional medicine, and Mellissa officinalis or Lemon Balm (LB) that there are some evidence indicating for its application as analgesics or its probable analgesic effect was selected for evaluation of analgesic effect by tail-flick test in mice. After scientific identification, the leaves and flowered branches ...