background: acute promyelocytic leukemia (apl) is a unique subtype of acute leukemia. apl is a curable disease; however, drug resistance, early mortality, disease relapse and treatment-related complications remain challenges in apl patient management. one issue underlying these challenges is that the molecular mechanisms of the disease are not sufficiently understood. materials and methods: in ...

background :    although, nontuberculous mycobacteria can cause disease in different organisms, they usually are not reported in most countries because scientists in general consider them as non-pathogens. but, increasing nontuberculous mycobacteria diseases occurrence has changed this belief. nevertheless, there is no meta-analysis review about prevalence of nontuberculous mycobacteria in iran...

metallothionein (mt) manifests varying expression levels in carcinomas, and they may be considered as valuable cell cancerization biomarkers for diagnosis of patients with cancers. a meta-analysis was conducted to evaluate comprehensively the mt expression difference in various benign tumors and malignant tumors, which compared the high with low mt expression levels in patients of the available...

leviteracetam (lev) is a novel antiepileptic drug with improved tolerance and safety, while carbamazepine (cbz) represents classical antiepileptic drugs. so far, a systemic comparison of the efficacy and side effects of these two drugs is lacking. a literature review on the comparison of leviteracetam versus carbamazepine for patients with epilepsy was performed up to september 2013 using pubme...

introduction: enuresis is the second most common disorder among children after allergic disorders. according to the results of previous studies, different estimates of enuresis prevalence and its related factors have been reported. combining the results of these studies is valuable. this study aims to estimate the prevalence of enuresis and its related factors among iranian children.materials a...

conclusions cp is effective for inducing clinical response and maintenance of clinical remission in patients with moderate to severe cd with similar side-effect profile as the control arms. background tumor necrosis factor-α (tnf-α) antibodies are currently used in patients with moderate to severe crohn’s disease (cd) who are unresponsive to conventional therapies. certolizumab pegol (cp) is on...

obesity is one of the main public health problems which underlie many chronic illnesses and socioeconomic difficulties. according to the literature review, there are limited data on the prevalence of obesity in different parts of iran as well as its trend and prevalence among different age and gender groups. the aim of this study was to estimate the obesity prevalence in iran using meta-analysi...