The SARS-CoV2 virus, which causes COVID-19, exerts its pathophysiological effect by intensively binding to the angiotensin-converting enzyme 2 receptor (ACE2) on host cells. By blocking ACE2 receptor, physiological functions of cell are inhibited, important for normal function various organs, and especially protection lungs. Therefore, number functionally active receptors is extremely body's re...

In 2019, the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), has killed more than 6.6 millions of people around world as end 2022. The long-term impact COVID-19 is persisted, including its on male reproduction. SARS-CoV-2 enters into host cells using angiotensin-converting enzyme (ACE2) and transmembrane serine protease (TMP...

We investigated the binding characteristics of angiotensin receptors and used this assay to determine the predominant enzyme capable of converting angiotensin I in the human left ventricle. In homogenates of human left ventricle, (125)I-[Sar(1),Ile(8)]angiotensin II bound with sub-nanomolar affinity, with a corresponding K(D) of 0.42+/-0.09 nM, a B(max) of 11.2+/-2.3 fmol.mg(-1) protein and a H...

Responses to the synthetic substrate [Pro11,d-Ala12]angiotensin I were investigated in the hindlimb vascular bed of the cat, a system in which local angiotensin-converting enzyme activity is high. Under constant-flow conditions, injections of [Pro11,d-Ala12]angiotensin I into the perfusion circuit in doses of 1-300 μg caused dose-related increases in perfusion pressure that were rapid in onset ...

Objective(s): Stress alters sensory and cognitive function in humans and animals. Angiotensin (AT) receptors have demonstrated well-established interactions in sets of physiological phenomena. AT1 receptors can play a part in stress-induced activation of hypothalamic-pituitary-adrenal (HPA) axis; besides angiotensinergic neurotransmission plays a pivotal role in stress-evoked physiological resp...

Objective: Many chronic diseases, such as hypertension, diabetes, and coronary heart disease, paving the way for disease to progress unfavorably in Covid-19. Angiotensin-converting enzyme inhibitors (ACEIs) angiotensin-2 receptor blockers (ARBs) can upregulate ACE2 receptors (which SARS-COV-2 uses enter host cell) or protect against infection by limiting effects of Angiotensin 2. This study aim...

Angiotensin (Ang) II exerts its important physiological functions through 2 distinct receptor subtypes, type 1 (AT(1)) and type 2 (AT(2)) receptors. Recently, new evidence has accumulated showing the existence of several novel receptor interacting proteins and various angiotensin II receptor activation mechanisms beyond the classical actions of receptors for Ang II. These associated proteins co...

Dipeptidyl peptidase IV converts neuropeptide Y(1-36) (Y(1)-receptor agonist released from renal sympathetic nerves) to neuropeptide Y(3-36) (selective Y(2)-receptor agonist). Previous studies suggest that Y(1), but not Y(2), receptors enhance renovascular responses to angiotensin II in kidneys from genetically-susceptible animals. Therefore, we hypothesized that inhibition of dipeptidyl peptid...

The l-sarcosine-8-alanine analogue of angiotensin II (l-Sar-8-Ala-angiotensin II) was infused at 1 and 5 /ig/kg min~' into conscious rabbits on normal or sodium-deficient diets. Blood pressures during the control period were comparable in both groups; plasma renin activity, angiotensin II concentration, and aldosterone concentration were higher in the rabbits on the sodium-deficient diet than t...

1. The effects on phosphatidylinositol metabolism of three Ca(2+)-mobilizing glycogenolytic hormones, namely angiotensin, vasopressin and adrenaline, have been investigated by using rat hepatocytes. 2. All three hormones stimulate both phosphatidylinositol breakdown and the labelling of this lipid with (32)P. 3. The response to angiotensin occurs quickly, requires a high concentration of the ho...